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Related Concept Videos

Inflammation01:38

Inflammation

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Overview
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Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
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Tissues01:25

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Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
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Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
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Plant tissue culture is widely used in both primary and applied science. Applications range from plant development studies to functional gene studies, crop improvement, commercial micropropagation, virus elimination, and conservation of rare species.
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Tissue Membranes01:27

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A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
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Updated: Jan 29, 2026

Author Spotlight: Insights into Cardiometabolic Diseases with Subcutaneous Adipose Tissue Microvasculature Studies
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How Adipocytes Orchestrate Inflammation Within Adipose Tissue?

Romane Higos1, Gianluca Renzi2, Paul Taillandier1

  • 1Nutrition and Obesities: Systemic Approach Research Group, Nutriomics, Sorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), 75013 Paris, France.

Biomolecules
|January 28, 2026
PubMed
Summary
This summary is machine-generated.

Adipose tissue, an active endocrine organ, initiates a fibro-inflammatory response to chronic nutrient excess. This response leads to maladaptive adipocyte phenotypes, contributing to obesity-related inflammation and insulin resistance.

Keywords:
adipocytefibro-inflammationobesity

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Area of Science:

  • Metabolic and endocrine functions of adipose tissue.
  • Cellular and molecular mechanisms of obesity.

Background:

  • Adipose tissue acts as a metabolic and endocrine organ regulating energy balance.
  • Chronic caloric surplus leads to adipocyte dysfunction, metabolic stress, and inflammation.

Purpose of the Study:

  • To review the cellular and molecular triggers of fibro-inflammation in adipose tissue.
  • To understand how these processes alter adipocyte identity and tissue homeostasis.

Main Methods:

  • Literature review of cellular and molecular cues.
  • Analysis of nutrient excess, mitochondrial stress, hypoxia, and immunometabolic rewiring.

Main Results:

  • Adipocytes initiate a fibro-inflammatory response to chronic nutrient excess and stress.
  • This chronic response results in loss of metabolic flexibility and maladaptive phenotypes.
  • Fibro-inflammation contributes to systemic inflammation, insulin resistance, and metabolic disease.

Conclusions:

  • Fibro-inflammation is a key process in obesity pathogenesis.
  • Understanding these triggers is crucial for addressing metabolic diseases.