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Related Experiment Video

Updated: Jan 29, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

Sarcopenia Predicts Mortality in Bladder Cancer with Neoadjuvant Chemotherapy: A Multicenter Study.

Alice Pitout¹, Charles Mazeaud^1,2, Alicia Blondeau¹

¹Department of Urology, CHRU de Nancy, 54500 Vandoeuvre -lès-Nancy, France.

|January 28, 2026

Summary

This summary is machine-generated.

Sarcopenia, a measure of muscle mass, is a significant predictor of mortality in bladder cancer patients undergoing neoadjuvant chemotherapy. This study highlights its prognostic value and compares different measurement thresholds for improved clinical assessment.

Keywords:

bladder cancer body composition chemotherapy neoadjuvant sarcopenia

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Area of Science:

Oncology
Radiology
Geriatrics

Background:

Sarcopenia, assessed via CT scans, is a known negative prognostic factor in various cancers.
Its role in bladder cancer patients receiving neoadjuvant chemotherapy is not well-established.
This research investigates sarcopenia's prognostic impact on survival outcomes in this specific patient group.

Purpose of the Study:

To evaluate the prognostic significance of sarcopenia on survival in bladder cancer patients.
To compare different sarcopenia measurement thresholds and their impact on prognostic accuracy.
To assess sarcopenia's association with progression-free survival (PFS) and pathological complete response (pCR).

Main Methods:

Retrospective multicenter study of 74 invasive urothelial carcinoma patients treated with neoadjuvant chemotherapy and cystectomy (2015-2021).
Sarcopenia assessed using Skeletal Muscle Index on CT scans before chemotherapy (BC) and before surgery (BS).
Primary endpoint: overall survival. Secondary endpoints: PFS, pCR, treatment complications.

Main Results:

Sarcopenia prevalence was 27% BC and 39% BS.
Sarcopenia was significantly associated with increased all-cause mortality (HR 3.38-6.08, p=0.012-0.032) and shorter PFS.
Forty percent achieved pCR, 35% had recurrence; median PFS was 25 months.

Conclusions:

Sarcopenia is an independent and reproducible prognostic factor for mortality in bladder cancer patients.
The study provides the first comparison of sarcopenia threshold values at different time points (BC vs. BS).
Findings suggest incorporating sarcopenia assessment into clinical practice for risk stratification.