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Updated: Jan 29, 2026
08:39
Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
5.4K
Sarcopenia Predicts Mortality in Bladder Cancer with Neoadjuvant Chemotherapy: A Multicenter Study
Alice Pitout1, Charles Mazeaud1,2, Alicia Blondeau1
1Department of Urology, CHRU de Nancy, 54500 Vandoeuvre -lès-Nancy, France.
Cancers
|January 28, 2026
Summary
Sarcopenia, a measure of muscle mass, is a significant predictor of mortality in bladder cancer patients undergoing neoadjuvant chemotherapy. This study highlights its prognostic value and compares different measurement thresholds for improved clinical assessment.
Area of Science:
- Oncology
- Radiology
- Geriatrics
Background:
- Sarcopenia, assessed via CT scans, is a known negative prognostic factor in various cancers.
- Its role in bladder cancer patients receiving neoadjuvant chemotherapy is not well-established.
- This research investigates sarcopenia's prognostic impact on survival outcomes in this specific patient group.
Purpose of the Study:
- To evaluate the prognostic significance of sarcopenia on survival in bladder cancer patients.
- To compare different sarcopenia measurement thresholds and their impact on prognostic accuracy.
- To assess sarcopenia's association with progression-free survival (PFS) and pathological complete response (pCR).
Main Methods:
- Retrospective multicenter study of 74 invasive urothelial carcinoma patients treated with neoadjuvant chemotherapy and cystectomy (2015-2021).
- Sarcopenia assessed using Skeletal Muscle Index on CT scans before chemotherapy (BC) and before surgery (BS).
- Primary endpoint: overall survival. Secondary endpoints: PFS, pCR, treatment complications.
Main Results:
- Sarcopenia prevalence was 27% BC and 39% BS.
- Sarcopenia was significantly associated with increased all-cause mortality (HR 3.38-6.08, p=0.012-0.032) and shorter PFS.
- Forty percent achieved pCR, 35% had recurrence; median PFS was 25 months.
Conclusions:
- Sarcopenia is an independent and reproducible prognostic factor for mortality in bladder cancer patients.
- The study provides the first comparison of sarcopenia threshold values at different time points (BC vs. BS).
- Findings suggest incorporating sarcopenia assessment into clinical practice for risk stratification.
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