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Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach
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The Role of TARE for Bridging and Downstaging of HCC Before Resection or Liver Transplant

Abdullah Alshamrani1, Sung Ki Cho2, Namkee Oh1

  • 1Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.

Cancers
|January 28, 2026
PubMed

Insights

Transarterial radioembolization (TARE) effectively bridges hepatocellular carcinoma (HCC) patients to curative surgery. This treatment supports favorable long-term survival, with careful patient selection crucial for optimizing outcomes.

Area of Science:

  • Hepatology
  • Oncology
  • Interventional Radiology

Background:

  • Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide.
  • Locoregional therapies like transarterial radioembolization (TARE) are used to manage HCC.
  • TARE aims to downstage tumors and improve eligibility for curative treatments.

Purpose of the Study:

  • To evaluate the efficacy of TARE as a bridge to curative surgery in HCC patients.
  • To assess the long-term oncological outcomes, including overall survival (OS) and disease-free survival (DFS).

Main Methods:

  • Retrospective analysis of 25 HCC patients treated with TARE as neoadjuvant therapy.
  • Assessment of TARE's role in facilitating subsequent surgical resection or liver transplantation.
  • Evaluation of patient survival data (OS and DFS) via Kaplan-Meier analysis.

Main Results:

  • 17 patients underwent surgical resection, and 8 received living-donor liver transplantation (LDLT).
  • Median DFS was 11.2 months; median OS for the cohort was 33.4 months.
  • 76% of patients were alive and disease-free at last follow-up; LDLT group showed sustained OS.

Conclusions:

  • TARE is a viable bridging strategy for selected HCC patients, enabling curative-intent surgery.
  • TARE contributes to favorable long-term oncological outcomes and survival benefits.
  • Optimizing outcomes requires careful patient selection and multidisciplinary management.

Keywords:
hepatocellular carcinoma (HCC)living-donor liver transplant (LDLT)surgical resectiontransarterial radioembolization (TARE)

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