Lifestyle, Modifiable Behavioral Factors, and Biomarker Profiles in Uterine Lesions

Area of Science:

• Gynecology
• Oncology
• Public Health

Background:

• Lifestyle factors such as obesity, low physical activity, and poor diet are linked to endometrial lesions and cancer.
• Early identification of these risk factors is crucial for prevention and enhancing women's health literacy.

Purpose of the Study:

• To assess how modifiable lifestyle factors influence the risk of endometrial hyperplasia without atypia (EIN) and endometrial cancer compared to leiomyoma.
• To investigate the association between lifestyle factors and the development of precursor and malignant endometrial conditions.

Main Methods:

• A cross-sectional study involving 50 women across three groups: leiomyoma, EIN, and endometrial cancer.
• Assessment of Body Mass Index (BMI), physical activity, diet, sleep, stress, and smoking status.
• Statistical analysis using Kruskal-Wallis test, correlation, and logistic regression.

Main Results:

• Elevated BMI was an independent predictor for EIN/endometrial cancer (OR=1.29, p=0.015).
• Women with EIN/endometrial cancer exhibited significantly lower physical activity levels (p=0.018).
• Higher BMI correlated with increased stress and reduced sleep duration, indicating a cluster of behavioral risks.

Conclusions:

• Modifiable lifestyle factors are pivotal in the development of precursor and malignant endometrial conditions.
• Interventions targeting weight management, physical activity, and health literacy can mitigate risk and improve quality of life for peri- and postmenopausal women.