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Updated: Jan 29, 2026
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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
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Association of Gene Polymorphism at Atrial Fibrillation in the Kazakh Population: Case-Control Study
Dana Taizhanova1, Nazira Bazarova2, Akerke Kalimbetova3
1Department of Internal Diseases, Karaganda Medical University, 40 Gogolya Street, Karaganda 100000, Kazakhstan.
Genes
|January 28, 2026
Summary
Genetic factors influence atrial fibrillation (AF) risk. This study found no statistically significant association between the PRRX1 gene rs3903239 polymorphism and AF in the Kazakh population.
Area of Science:
- Cardiovascular Genetics
- Population Genetics
- Molecular Cardiology
Background:
- Atrial fibrillation (AF) is a prevalent cardiac arrhythmia with significant public health implications.
- Genetic predisposition, including variants influencing atrial remodeling, plays a role in AF susceptibility.
Purpose of the Study:
- To investigate the association between the PRRX1 gene rs3903239 polymorphism and atrial fibrillation (AF) in a Kazakh population.
- To compare genotype and allele frequencies of rs3903239 between AF patients and control groups.
Main Methods:
- A case-control study involving 75 AF patients and 123 controls (73 healthy, 50 with arterial hypertension/coronary heart disease).
- Genotyping of the PRRX1 gene rs3903239 polymorphism.
- Analysis of genotype and allele frequencies, assessing Hardy-Weinberg equilibrium.
Main Results:
- The frequency of the rare G allele (AG + GG genotypes) was numerically higher in AF patients compared to healthy controls.
- This observed difference did not reach statistical significance (OR 1.357; 95% CI 0.845-2.178).
Conclusions:
- The study did not find a statistically confirmed association between the PRRX1 gene rs3903239 polymorphism and AF in the studied Kazakh population.
- The observed trend suggests further investigation may be warranted, but current data do not support a genetic link.
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