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Film Extrusion of Crambe abyssinica/Wheat Gluten Blends
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Rethinking Celiac Disease Management: Treatment Approaches Beyond the Gluten-Free Diet
Dimitris Kounatidis1, Argyro Pavlou2, Apostolos Evangelopoulos3
1Diabetes Center, First Propaedeutic Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece.
Biomedicines
|January 28, 2026
Summary
Celiac disease (CeD) treatments beyond a gluten-free diet are emerging to address persistent symptoms. Novel therapies target inflammation, immune response, and gut barrier function, with advanced technologies accelerating research.
Area of Science:
- Immunology
- Gastroenterology
- Translational Medicine
Background:
- Celiac disease (CeD) is an immune-mediated enteropathy triggered by gluten.
- It is a systemic condition with diverse symptoms, affecting patients across all ages.
- A gluten-free diet (GFD) is standard, but 30-40% of patients have persistent symptoms or mucosal injury.
Purpose of the Study:
- To review current and emerging therapies for CeD beyond the GFD.
- To examine challenges in clinical implementation of new treatments.
- To discuss the role of technological innovations in CeD therapy development.
Main Methods:
- Literature review of studies on CeD therapies.
- Synthesis of evidence for intraluminal, immunological, and barrier-enhancing strategies.
- Discussion of advanced platforms like organoids and machine learning.
Main Results:
- Multiple novel therapeutic strategies are under investigation.
- These include gluten-degrading enzymes, immune modulators (e.g., targeting IL-15), and gut barrier enhancers.
- Advanced technologies are accelerating the development of precision medicine approaches.
Conclusions:
- Therapies beyond the GFD are crucial for managing CeD.
- Overcoming challenges in clinical implementation is key.
- Technological innovations promise to reshape the future therapeutic landscape for CeD.
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