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Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
Published on: February 15, 2019
Advances in Understanding the Impact of Human Gut Microbiota on Chemotherapy-Induced Neutropenia
Mengyuan He1, Liangkang Lin1, Cheng Ouyang1
1Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
Abstract:
Neutrophils play a crucial role in defending against bacterial and fungal pathogens; however, chemotherapy reduces neutrophil counts, increasing infection risk and worsening cancer treatment outcomes. Emerging evidence highlights the gut microbiota as a promising biomarker and therapeutic target for chemotherapy-induced neutropenia (CIN). Here, we review current knowledge regarding the relationship between the gut microbiota and CIN, summarizing the mechanisms by which the microbiota influence neutrophil dynamics, current therapeutic approaches, and limitations in regard to preserving microbiota stability. This review offers a theoretical foundation for "gut-protective" chemotherapy, potentially facilitating personalized treatments, although clinical translation remains challenging.
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