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The Mechanism and Regulation of Disulfidptosis and Its Role in Disease

Yiming Wan1, Mengjia Jing1, Lumiao Zhang1

  • 1Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Biomedicines
|January 28, 2026
PubMed

Insights

Disulfidptosis, a novel regulatory cell death (RCD), involves disulfide bond accumulation. This mechanism offers potential therapeutic strategies for cancer and chronic diseases.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Disulfidptosis is a newly discovered form of regulatory cell death (RCD).
  • It is characterized by the accumulation of protein disulfide bonds, distinguishing it from other RCDs.
  • This pathway presents potential therapeutic avenues for cancer and chronic diseases.

Purpose of the Study:

  • To review the molecular mechanisms of disulfidptosis.
  • To explore inhibitors, regulatory networks, and connections to other RCD pathways.
  • To discuss the application of disulfidptosis in cancer and chronic diseases, identifying future research directions.

Main Methods:

  • Literature review and synthesis of existing research on disulfidptosis.
  • Analysis of molecular pathways and regulatory networks.
  • Comparative analysis with other regulatory cell death mechanisms.

Main Results:

  • Disulfidptosis is mechanistically distinct due to disulfide bond accumulation.
  • It involves specific molecular players and regulatory networks.
  • Emerging evidence highlights its role in tumor suppression and chronic disease modulation.

Conclusions:

  • Disulfidptosis represents a significant advancement in understanding cell death.
  • Targeting disulfidptosis may offer novel therapeutic strategies for various diseases.
  • Further research is needed to fully elucidate its complexities and clinical applications.
Keywords:
NADPHSLC7A11chronic diseasescysteinecystinedisulfidptosisprotein disulfide bondsregulatory deathtumors

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