Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alveoli and Alveolar Ducts01:26

Alveoli and Alveolar Ducts

5.7K
The respiratory zone of the human body, which stands in contrast to the conducting zone, comprises the structures that actively participate in the exchange of gases. The initiation of this zone is marked by the terminal bronchioles converging into respiratory bronchioles, the tiniest bronchiole classification. The respiratory bronchioles give way to the alveolar ducts that opens into a congregation of alveoli. Actively involved in gas exchange, alveoli resemble tiny sacs similar to clusters of...
5.7K
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

1.9K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.9K
Defenses Against Pathogens and Herbivores02:26

Defenses Against Pathogens and Herbivores

29.6K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
29.6K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.8K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.8K
Typical Model Studies01:30

Typical Model Studies

632
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
632
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

283
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
283

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-Wide Characterization of TCP Transcription Factors in Common Glasswort (<i>Salicornia europaea</i>) and Their Expression Analysis Under Salt Stress.

International journal of molecular sciences·2026
Same author

Organoid bioprinting for vascularized tumor assembloids.

Trends in biotechnology·2026
Same author

Profiling of extracellular vesicle-associated microRNAs reveals a regulated response to potato virus Y infection in tomato.

Frontiers in genetics·2026
Same author

A novel GelMA-SPAK hydrogel with affinity-controlled release of bFGF towards wound healing.

Biofabrication·2026
Same author

3D-printed polycaprolactone combined with cartilage acellular matrix tissue engineered cartilage scaffold manufactured by low-temperature deposition manufacturing.

Frontiers in bioengineering and biotechnology·2025
Same author

Analysis the status and spatio-temporal characteristics of the synergistic development of China's multi-level medical insurance system.

Scientific reports·2025
Same journal

Correction: Komatsu et al. Three-Dimensional Visualization and Detection of the Pulmonary Venous-Left Atrium Connection Using Artificial Intelligence in Fetal Cardiac Ultrasound Screening. <i>Bioengineering</i> 2026, <i>13</i>, 100.

Bioengineering (Basel, Switzerland)·2026
Same journal

Comparison of CO<sub>2</sub> Laser and Microdebrider in the Surgical Treatment of Pediatric Recurrent Respiratory Papillomatosis: A Retrospective Analysis.

Bioengineering (Basel, Switzerland)·2026
Same journal

Toward More Translational Tumor Models: Breast dECM-Based 3D Systems Capture Native Microenvironmental Cues.

Bioengineering (Basel, Switzerland)·2026
Same journal

Postural Stability Changes During the 4 Phases of the Half Squat: Kinematics Profile of the Center of Pressure and Center of Mass in High-Performance Weightlifters-A Pilot Study.

Bioengineering (Basel, Switzerland)·2026
Same journal

Definite Implant Position as Novel Readout for Effectiveness of Ridge Preservation Indicates to Beneficial Effect of Combined Treatment with Platelet-Rich Fibrin (PRF) and Xenogenic Biomaterial in Bone Regeneration.

Bioengineering (Basel, Switzerland)·2026
Same journal

Trueness and Precision of Intraoral Scanners for 3D-Printed Orthodontic Models with Attachments: An In Vitro Comparative Study.

Bioengineering (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms
10:30

Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms

Published on: May 31, 2024

2.2K

Hydrogel Microsphere-Based Alveolar Models for Toxicity Assessment and Pathogen Infection Studies.

Chang Zhou1, Jingyuan Ji1, Meiling Fu1

  • 1Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Haidian District, Beijing 100084, China.

Bioengineering (Basel, Switzerland)
|January 28, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel biomimetic alveolar model using hydrogel microspheres. This innovative system accurately mimics the lung

Keywords:
alternative to animal experimentsalveolar modelhydrogel microspherespathogen infectiontoxicity assessment

More Related Videos

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
09:23

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex

Published on: June 30, 2019

12.5K
Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies
14:48

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies

Published on: December 26, 2012

27.2K

Related Experiment Videos

Last Updated: Jan 29, 2026

Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms
10:30

Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms

Published on: May 31, 2024

2.2K
Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
09:23

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex

Published on: June 30, 2019

12.5K
Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies
14:48

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies

Published on: December 26, 2012

27.2K

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Respiratory Physiology

Background:

  • The alveolar epithelium is crucial for gas exchange and lung defense.
  • Reconstructing the complex 3D alveolar structure in vitro is challenging.
  • Existing models do not fully replicate the alveolar microenvironment.

Purpose of the Study:

  • To create a biomimetic alveolar model for studying respiratory function and disease.
  • To overcome the limitations of current in vitro lung models.
  • To provide a versatile platform for respiratory research and drug screening.

Main Methods:

  • Fabrication of gelatin methacryloyl (GelMA) hydrogel microspheres using microfluidic technology.
  • Utilizing an oxygen-permeable honeycomb microwell array for rapid assembly of cell-laden microspheres.
  • Developing physiologically relevant alveolar-like structures with controlled size and composition.

Main Results:

  • The GelMA microspheres served as effective micro-scaffolds for cell growth.
  • The system successfully assembled into alveolar-like structures.
  • The model was used to investigate the effects of toxic gas exposure and pathogen infection.

Conclusions:

  • The biomimetic alveolar model recapitulates key features of the native alveolar microenvironment.
  • This platform offers a promising tool for basic physiological studies and pathological applications.
  • The system demonstrates potential for respiratory research and pharmaceutical drug screening.