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Emerging Therapeutic Strategies for Nrf2-Associated Skin Disorders: From Photoaging to Autoimmunity

Hyeong Jae Kim1, Jeong Hee Hong1

  • 1Department of Physiology, College of Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 155 Getbeolro, Yeonsu-gu, Incheon 21999, Republic of Korea.

Antioxidants (Basel, Switzerland)
|January 28, 2026
PubMed

Insights

Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates antioxidant responses. This review explores Nrf2's role in skin conditions like photoaging and psoriasis, and potential natural compounds for treatment.

Area of Science:

  • Dermatology and Molecular Biology
  • Focuses on the molecular mechanisms of skin aging and disease.

Background:

  • Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of cellular antioxidant and detoxification pathways.
  • Dysfunctional Nrf2 signaling is implicated in various skin disorders, including photoaging, autoimmune conditions, and fibrosis.
  • Oxidative stress plays a significant role in the pathogenesis of these cutaneous pathologies.

Purpose of the Study:

  • To review the multifaceted roles of Nrf2 in skin physiology and pathology.
  • To highlight Nrf2's involvement in oxidative stress, autoimmune skin damage, and fibrotic diseases.
  • To explore natural compounds and delivery systems for modulating Nrf2 signaling to treat skin disorders.

Main Methods:

  • Comprehensive literature review of studies on Nrf2 signaling in skin.
  • Analysis of Nrf2's role in specific conditions: photoaging, psoriasis, vitiligo, and autoimmune skin fibrosis.
  • Evaluation of natural bioactive compounds and their therapeutic potential via Nrf2 modulation.

Main Results:

  • Nrf2 is crucial for maintaining skin homeostasis and combating oxidative stress.
  • Impaired Nrf2 function contributes to the development and progression of photoaging, psoriasis, vitiligo, and fibrotic skin diseases.
  • Several natural compounds demonstrate potential in activating Nrf2 pathways to protect against skin damage.

Conclusions:

  • Nrf2 signaling is a critical therapeutic target for a spectrum of skin disorders driven by oxidative stress.
  • Natural compounds offer promising avenues for developing novel treatments by modulating Nrf2.
  • Translating Nrf2-based research into clinical applications could significantly improve management of oxidative stress-related skin conditions.
Keywords:
Nrf2autoimmune diseasesfibrotic diseaseoxidative stressphotoaging

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