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Updated: Jan 29, 2026
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Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains
Published on: March 25, 2015
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The Zinc Finger Ran-Binding Protein 3 (ZRANB3): An Advanced Perspective
Paride Pelucchi1, Ettore Mosca1, Nika Tomsič2
1Istituto di Tecnologie Biomediche (ITB), Consiglio Nazionale delle Ricerche (CNR), Via Fratelli Cervi 93, 20054 Milano, Italy.
International Journal of Molecular Sciences
|January 28, 2026
Summary
Human ZRANB3 protein is vital for DNA damage tolerance and genome stability, acting as a tumor suppressor. Its altered expression in cancer correlates with poor survival, highlighting its prognostic potential.
Area of Science:
- Molecular Biology
- Genetics
- Cancer Research
Background:
- Human zinc finger Ran-binding protein 3 (ZRANB3) is essential for DNA damage tolerance (DDT).
- ZRANB3 functions in replication fork reversal (RFR) and the p53/Polι pathway, implicating it as a tumor suppressor.
- Deregulation of ZRANB3 in tumors is linked to adverse clinical outcomes.
Purpose of the Study:
- To comprehensively review the gene and protein-level literature on ZRANB3.
- To examine ZRANB3 regulation in cancer development.
- To discuss evidence for ZRANB3's role as a tumor suppressor and prognostic biomarker.
Main Methods:
- Literature review integrating gene and protein data.
- Analysis of ZRANB3's role in DNA damage tolerance and replication fork dynamics.
- Examination of ZRANB3 alterations (mutations, copy number) in cancer.
Main Results:
- ZRANB3 maintains genome stability by preventing DNA damage and restoring fork progression.
- ZRANB3 expression is frequently deregulated in tumors, correlating with poor prognosis.
- The correlation between ZRANB3 mRNA and p53 expression is context-dependent, particularly in p53-mutated cancers.
Conclusions:
- ZRANB3 is a critical tumor suppressor involved in DNA repair pathways.
- Altered ZRANB3 is a significant prognostic biomarker in various cancers.
- Further research into ZRANB3's functions in DNA synthesis and metabolism is warranted.
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