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An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
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Molecular Landscape of Advanced Endometrial Cancer: Exploratory Analyses at Modena Cancer Center (MEMO)
Marta Pirola1, Eleonora Molinaro2, Samantha Manfredini3
1Division of Oncology, University of Modena and Reggio Emilia, 41124 Modena, Italy.
International Journal of Molecular Sciences
|January 28, 2026
Summary
Advanced endometrial cancer has a poor prognosis. Molecular profiling revealed specific gene mutations (CTNNB1, KRAS) associated with patient outcomes, suggesting new therapeutic targets for this disease.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- The prognosis for advanced endometrial cancer remains poor despite new treatments.
- Molecular characterization is gaining importance, but data on advanced stages are limited.
Purpose of the Study:
- To explore the molecular landscape of advanced or recurrent endometrial cancer.
- To identify genomic alterations associated with clinical subgroups and overall survival.
Main Methods:
- Retrospective analysis of 32 advanced/recurrent endometrial cancer patients.
- Comprehensive molecular profiling including DNA mutations, copy number variations, and RNA expression.
Main Results:
- High prevalence of PTEN and PIK3CA mutations observed.
- CTNNB1 mutations linked to later relapse and favorable prognosis.
- KRAS mutations associated with younger patients, endometrioid histology, and poorer survival.
- PPP2R1A and TP53 mutations enriched in non-endometrioid histology.
Conclusions:
- Specific gene mutations (CTNNB1, KRAS) impact prognosis in advanced endometrial cancer.
- Further research is needed to explore targeted therapies based on molecular alterations.
- Combinatorial strategies targeting KRAS warrant investigation for improved treatment outcomes.
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