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Related Experiment Video

Updated: Jan 29, 2026

Chromatographic Purification of Highly Active Yeast Ribosomes
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Yeast Efficiently Utilizes Ribosomal RNA-Derived Oligonucleotides as Bioavailable Nutrient Sources.

Xinmei Du1, Qitao Chen1, Jingyun Zhuang1

  • 1College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.

Foods (Basel, Switzerland)
|January 28, 2026
PubMed
Summary

Yeast efficiently uses ribosomal RNA (rRNA)-derived oligonucleotides as a nutrient source, supporting cell growth. This highlights the nutritional potential of these RNA fragments in food and fermentation.

Keywords:
autophagyendocytosisoligonucleotide nutrient sourcesproteomicsrRNA-derived oligonucleotidesyeast

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nutritional Science

Background:

  • Nucleic acids are vital dietary components with established roles.
  • Research has focused on nucleotides, nucleosides, and microRNAs.
  • The nutritional value of ribosomal RNA (rRNA)-derived oligonucleotides, prevalent in food, is largely unknown.

Purpose of the Study:

  • To investigate the uptake and utilization of rRNA-derived oligonucleotides in yeast.
  • To explore the nutritional potential of these RNA fragments as a food source.

Main Methods:

  • Yeast was used as a model organism.
  • Confocal microscopy tracked labeled RNA oligonucleotide uptake.
  • Proteomic analysis identified cellular pathways involved.

Main Results:

  • Yeast efficiently utilized short RNA oligonucleotides (5-30 nt) for growth.
  • Rapid cellular uptake of RNA oligonucleotides was confirmed.
  • Endocytosis and autophagy pathways were upregulated in yeast fed RNA oligonucleotides.

Conclusions:

  • Yeast can internalize and metabolize rRNA-derived oligonucleotides as nutrients.
  • This process likely involves coordinated endocytic and autophagic pathways.
  • Findings support the application of rRNA-derived oligonucleotides in functional foods and fermentation.