Related Experiment Video
Updated: Jan 29, 2026
09:13
Chromatographic Purification of Highly Active Yeast Ribosomes
Published on: October 24, 2011
17.4K
Yeast Efficiently Utilizes Ribosomal RNA-Derived Oligonucleotides as Bioavailable Nutrient Sources
Xinmei Du1, Qitao Chen1, Jingyun Zhuang1
1College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.
Foods (Basel, Switzerland)
|January 28, 2026
Summary
Yeast efficiently uses ribosomal RNA (rRNA)-derived oligonucleotides as a nutrient source, supporting cell growth. This highlights the nutritional potential of these RNA fragments in food and fermentation.
Area of Science:
- Biochemistry
- Molecular Biology
- Nutritional Science
Background:
- Nucleic acids are vital dietary components with established roles.
- Research has focused on nucleotides, nucleosides, and microRNAs.
- The nutritional value of ribosomal RNA (rRNA)-derived oligonucleotides, prevalent in food, is largely unknown.
Purpose of the Study:
- To investigate the uptake and utilization of rRNA-derived oligonucleotides in yeast.
- To explore the nutritional potential of these RNA fragments as a food source.
Main Methods:
- Yeast was used as a model organism.
- Confocal microscopy tracked labeled RNA oligonucleotide uptake.
- Proteomic analysis identified cellular pathways involved.
Main Results:
- Yeast efficiently utilized short RNA oligonucleotides (5-30 nt) for growth.
- Rapid cellular uptake of RNA oligonucleotides was confirmed.
- Endocytosis and autophagy pathways were upregulated in yeast fed RNA oligonucleotides.
Conclusions:
- Yeast can internalize and metabolize rRNA-derived oligonucleotides as nutrients.
- This process likely involves coordinated endocytic and autophagic pathways.
- Findings support the application of rRNA-derived oligonucleotides in functional foods and fermentation.
Related Concept Videos
02:53Ribosomal RNA Synthesis
14.8K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.8K
02:53Ribosomal RNA Synthesis
4.4K
4.4K
01:27Ribosomes
75.4K
Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
75.4K
01:27Ribosomes
10.8K
Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
10.8K
01:28Yeast Signaling
17.2K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
17.2K
01:23Types of RNA
72.8K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.8K