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Biodegradable (PLGA) Implants in Pediatric Trauma: A Brief Review
Herman Nudelman1,2, Tibor Molnár1, Gergő Józsa1
1Department of Paediatrics, Clinical Complex, Division of Surgery, Traumatology and Otorhinolaryngology, University of Pécs, 7 József Attila Street, 7623 Pécs, Hungary.
Insights
Biodegradable poly(lactic-co-glycolic acid) (PLGA) implants offer a safe alternative for pediatric fracture fixation. These resorbable devices eliminate the need for removal surgery, reducing risks for children.
Area of Science:
- Biomaterials Science
- Pediatric Orthopedics
- Polymer Chemistry
Background:
- Metallic implants in pediatric orthopedic surgery necessitate removal, increasing risks.
- Biodegradable implants offer a solution by avoiding secondary surgeries.
- Poly(lactic-co-glycolic acid) (PLGA) is a key material in this field.
Purpose of the Study:
- Review the use of PLGA implants in pediatric fracture fixation.
- Evaluate their advantages over traditional metallic hardware.
- Assess safety and efficacy in pediatric trauma.
Main Methods:
- Conducted a narrative review of existing evidence and clinical data.
- Focused on PLGA's degradation mechanism and mechanical properties.
- Included studies on various pediatric fractures (forearm, ankle, etc.).
Main Results:
- PLGA implants showed effective healing and stable fixation comparable to metal.
- Complication rates were similar to traditional devices.
- Patients experienced reduced morbidity and no need for implant removal.
Conclusions:
- PLGA bioabsorbable implants are safe and effective for pediatric fracture fixation.
- Favorable degradation and performance support their use in pediatric trauma.
- Advances in polymer design will expand future applications.
Abstract:
Background/Objectives: Biodegradable implants have emerged as a promising alternative to traditional metallic fixation devices in pediatric orthopedic surgery. Avoiding implant removal is especially advantageous in children, who would otherwise require a second operation with additional anesthetic and surgical risks. This study reviews the current use of poly(lactic-co-glycolic acid) (PLGA) implants in pediatric fracture fixation and evaluates how they address limitations associated with traditional hardware. Methods: A narrative review was conducted summarizing current evidence, clinical experience, and case examples involving PLGA-based devices used in pediatric trauma. Special emphasis was placed on the degradation mechanism of PLGA, its controlled hydrolysis profile, and the capacity of the material to provide temporary mechanical stability during bone healing before complete resorption. The review included studies of PLGA use in forearm, distal radius, ankle, and elbow fractures, comparing outcomes to those obtained with metallic implants. Results: Across multiple clinical reports and case series, PLGA implants demonstrated effective fracture healing, stable fixation, and complication rates comparable to traditional metallic devices. Patients treated with resorbable implants benefited from reduced postoperative morbidity, no requirement for implant removal, and improved imaging compatibility. Conclusions: PLGA-based bioabsorbable implants represent a safe and effective alternative to conventional metal fixation in children. Their favorable degradation kinetics and clinical performance support their growing use in pediatric trauma surgery, while ongoing advances in polymer design and bioresorbable alloys continue to expand future applications.
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