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Updated: Jan 29, 2026
14:49
Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
Published on: April 15, 2022
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Biodegradable (PLGA) Implants in Pediatric Trauma: A Brief Review
Herman Nudelman1,2, Tibor Molnár1, Gergő Józsa1
1Department of Paediatrics, Clinical Complex, Division of Surgery, Traumatology and Otorhinolaryngology, University of Pécs, 7 József Attila Street, 7623 Pécs, Hungary.
Children (Basel, Switzerland)
|January 28, 2026
Summary
Biodegradable poly(lactic-co-glycolic acid) (PLGA) implants offer a safe alternative for pediatric fracture fixation. These resorbable devices eliminate the need for removal surgery, reducing risks for children.
Area of Science:
- Biomaterials Science
- Pediatric Orthopedics
- Polymer Chemistry
Background:
- Metallic implants in pediatric orthopedic surgery necessitate removal, increasing risks.
- Biodegradable implants offer a solution by avoiding secondary surgeries.
- Poly(lactic-co-glycolic acid) (PLGA) is a key material in this field.
Purpose of the Study:
- Review the use of PLGA implants in pediatric fracture fixation.
- Evaluate their advantages over traditional metallic hardware.
- Assess safety and efficacy in pediatric trauma.
Main Methods:
- Conducted a narrative review of existing evidence and clinical data.
- Focused on PLGA's degradation mechanism and mechanical properties.
- Included studies on various pediatric fractures (forearm, ankle, etc.).
Main Results:
- PLGA implants showed effective healing and stable fixation comparable to metal.
- Complication rates were similar to traditional devices.
- Patients experienced reduced morbidity and no need for implant removal.
Conclusions:
- PLGA bioabsorbable implants are safe and effective for pediatric fracture fixation.
- Favorable degradation and performance support their use in pediatric trauma.
- Advances in polymer design will expand future applications.
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