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Genetic Diversity of Aeromonas spp. Isolates from the Paediatric Population in Latvia Based on Multilocus Sequence

Irina Grave1,2, Aleksandra Rudzate1,2, Edvins Miklasevics1

  • 1Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia.

Children (Basel, Switzerland)
|January 28, 2026
PubMed

Insights

This study reveals significant genetic diversity among Aeromonas bacteria in Latvian children with gastroenteritis, identifying many novel strains. Findings highlight a unique local Aeromonas population, necessitating ongoing surveillance.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Molecular Epidemiology

Background:

  • Aeromonas species are increasingly recognized as significant pathogens, especially causing gastroenteritis in children.
  • Limited molecular data exists for Aeromonas strains in Latvia and the Baltic region.
  • Understanding genetic diversity is crucial for tracking pathogen evolution and spread.

Purpose of the Study:

  • To characterize the genetic diversity of Aeromonas isolates from pediatric gastroenteritis patients in Latvia.
  • To utilize multilocus sequence typing (MLST) for molecular profiling of these isolates.
  • To establish a baseline for Aeromonas epidemiology in the Baltic region.

Main Methods:

  • Collection of stool samples from pediatric gastroenteritis cases (0-18 years) at Children's Clinical University Hospital (2020-2021).
  • Random selection of 30 non-duplicate Aeromonas isolates for molecular characterization.
  • Analysis of isolates using multilocus sequence typing (MLST) with data submission to PubMLST.org.

Main Results:

  • MLST analysis demonstrated substantial genetic diversity, identifying 25 novel sequence types (STs).
  • Three isolates matched previously reported STs; two novel STs were found in duplicate cases.
  • The distribution of Aeromonas species and STs in Latvia differed from global datasets, suggesting a distinct local population.

Conclusions:

  • This is the first MLST-based characterization of pediatric Aeromonas isolates in Latvia.
  • Findings establish a regional baseline for future epidemiological studies in the Baltic area.
  • Continued surveillance is recommended, though the small sample size limits direct public health conclusions.

Keywords:
Aeromonasgastroenteritisgenetic diversitymultilocus sequence typing (MLST)paediatric

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