Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
Cancer Therapies02:49

Cancer Therapies

10.1K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.1K
Biological Effects of Radiation02:59

Biological Effects of Radiation

17.8K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.8K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

2.5K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
2.5K
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

4.8K
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
4.8K
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

6.6K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential Cytokine and DNA Damage Response of Human Lung Tissue Models to Broad-Beam and Microbeam Radiotherapy.

Cells·2026
Same author

Low-to-Moderate Dosed Cranial Irradiation in Young Mice Induces Sex-Specific Metabolic Disturbances Later in Life.

Diabetes·2025
Same author

The Combination of Temporal and Spatial Dose Fractionation in Microbeam Radiation Therapy.

Biomedicines·2025
Same author

Superior Anti-Tumor Response After Microbeam and Minibeam Radiation Therapy in a Lung Cancer Mouse Model.

Cancers·2025
Same author

Modernizing histopathological analysis: a fully automated workflow for the digital image analysis of the intestinal microcolony survival assay.

bioRxiv : the preprint server for biology·2024
Same author

Impact of Radiation on Invasion and Migration of Glioma In Vitro and In Vivo.

Cancers·2024
Same journal

RETRACTED: Bakshi et al. Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways. <i>Cells</i> 2022, <i>11</i>, 1502.

Cells·2026
Same journal

Correction: Verde et al. Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses. <i>Cells</i> 2025, <i>14</i>, 680.

Cells·2026
Same journal

Inflammation in Cardiomyopathies: Cellular Mechanisms Across Cardiac Phenotype.

Cells·2026
Same journal

IL-4/IL-13-Driven Dysregulation of Epidermal Lipid Metabolism in Atopic Dermatitis: An Immunometabolic Link Between Type 2 Inflammation and Barrier Dysfunction.

Cells·2026
Same journal

Activity of DNA- and RNA-Guided Prokaryotic Argonautes in Human Mitochondria.

Cells·2026
Same journal

Placental Pathophysiology in Maternal Psychoactive Substance Use: Biological, Clinical, and Forensic Perspectives.

Cells·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.2K

Targeting Lung Cancer Cell Motility Using Microbeam Radiation Therapy.

Ömer Dağkazanlı1,2, Aleksandra Čolić1,2, Rainer Lindner2

  • 1Department of Radiation Oncology, TUM School of Medicine and Health and Klinikum Rechts der Isar, University Hospital of the Technical University of Munich, Ismaninger Straße 22, 81675 Munich, Germany.

Cells
|January 28, 2026
PubMed
Summary
This summary is machine-generated.

Radiotherapy can increase lung cancer cell movement. Microbeam radiation therapy (MRT) prevented this, unlike broad beam radiation, potentially by reducing NF-κB expression.

Keywords:
CD44NF-κBinvasionirradiationmetastasismigrationspatial fractionation

More Related Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K

Related Experiment Videos

Last Updated: Jan 29, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.2K
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K

Area of Science:

  • Oncology
  • Radiation Oncology
  • Cancer Biology

Background:

  • Radiotherapy (RT) is a standard lung cancer treatment.
  • In vitro studies suggest irradiation may increase cancer cell motility and metastasis.
  • Safer and more effective RT modalities are needed.

Purpose of the Study:

  • Compare the effects of broad beam (BB) and microbeam radiation therapy (MRT) on lung cancer cell motility.
  • Investigate the role of NF-κB in observed effects.
  • Assess the impact of MRT on the tumor microenvironment, specifically fibroblasts.

Main Methods:

  • In vitro study using A549 lung cancer cells.
  • Irradiation with BB and MRT.
  • Analysis of cell motility and migration.
  • Measurement of NF-κB expression.
  • Co-culture experiments with irradiated MRC-5 lung fibroblasts.

Main Results:

  • BB irradiation increased A549 cell motility.
  • MRT irradiation prevented A549 cell migration.
  • NF-κB expression was significantly reduced by MRT.
  • Co-culturing with MRT-irradiated fibroblasts increased A549 cell invasion.

Conclusions:

  • MRT may offer a way to prevent RT-induced lung cancer cell motility.
  • Reduced NF-κB expression could be a mechanism for MRT's effect.
  • MRT irradiation of tumor microenvironment components like fibroblasts may enhance tumor cell invasion.