Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defining Psychology01:24

Defining Psychology

7.8K
Psychology is the scientific discipline dedicated to understanding both observable behavior and the internal mental processes underlying such behavior. It aims to comprehend human nature and apply this understanding to solve practical problems, enhance well-being, and improve societal outcomes. An example of psychology's application is the study of prosocial behavior, such as why and under what conditions individuals might help strangers in need. This process involves describing observed...
7.8K
Cluster Sampling Method01:20

Cluster Sampling Method

14.5K
Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
14.5K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

3.2K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
3.2K
Defining Social Psychology01:09

Defining Social Psychology

427
Social psychology investigates how the presence and actions of others influence individual behavior, cognition, and emotion. Examining the social environment's impact provides a scientific framework for understanding how individuals perceive others and are, in turn, influenced by them. This field seeks to uncover the underlying principles guiding social interactions, exploring phenomena such as conformity, obedience, and prosocial behavior.Core Themes in Social PsychologyOne central focus of...
427
Piecewise-Defined Functions01:28

Piecewise-Defined Functions

286
Piecewise defined functions are mathematical models where different expressions define a function over distinct intervals of the domain. These functions are useful for representing systems with varying behaviors depending on input values.For example, the function:  uses a linear rule for inputs less than or equal to –1 and a quadratic rule for values greater than –1. Although it has two formulas, it still defines a single function.Another common type is the absolute value...
286
Integration by Parts: Indefinite Integrals01:26

Integration by Parts: Indefinite Integrals

160
Integration by parts is a fundamental technique in calculus for evaluating integrals involving the product of two functions. It is particularly useful when direct integration is not feasible. The method is based on the product rule for differentiation, which states that the derivative of a product equals the derivative of the first function times the second, plus the first function times the derivative of the second. By integrating this identity and rearranging terms, the integration by parts...
160

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A patient with an adrenal metastasis and periadrenal lymph node metastases of a laryngeal squamous cell carcinoma: a case report.

Journal of medical case reports·2025
Same author

Role of GDH and PARP inhibitors as novel treatments for SDHB-deficient PPGLs.

Endocrine-related cancer·2025
Same author

The HLA region in ANCA-associated vasculitis: characterisation of genetic associations in a Scandinavian patient population.

RMD open·2024
Same author

Relation between HLA and copy number variation of steroid 21-hydroxylase in a Swedish cohort of patients with autoimmune Addison's disease.

European journal of endocrinology·2023
Same author

Domain landscapes of somatic NF1 mutations in pheochromocytoma and paraganglioma.

Gene·2023
Same author

Case report: Two sisters with a germline <i>CHEK2</i> variant and distinct endocrine neoplasias.

Frontiers in endocrinology·2022

Related Experiment Video

Updated: Jan 29, 2026

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

1.3K

Integrative Epigenomic and Transcriptomic Profiling Define Malignancy- and Cluster-Specific Signatures in

Mouna Tabebi1,2, Małgorzata Łysiak1,2, Oliver Gimm1,3

  • 1Department of Biomedical and Clinical Sciences (BKV), Linköping University, 58183 Linköping, Sweden.

Cells
|January 28, 2026
PubMed
Summary

This study reveals distinct DNA methylation and gene expression patterns in pheochromocytomas and paragangliomas (PPGLs). These epigenetic differences help distinguish tumor subtypes and identify markers for malignant progression in these rare neuroendocrine tumors.

Keywords:
TCGAmethylationpheochromocytoma/paragangliomatranscriptomic

More Related Videos

TChIP-Seq: Cell-Type-Specific Epigenome Profiling
07:28

TChIP-Seq: Cell-Type-Specific Epigenome Profiling

Published on: January 23, 2019

8.4K
Integrate Imaging Flow Cytometry and Transcriptomic Profiling to Evaluate Altered Endocytic CD1d Trafficking
09:01

Integrate Imaging Flow Cytometry and Transcriptomic Profiling to Evaluate Altered Endocytic CD1d Trafficking

Published on: October 29, 2018

7.1K

Related Experiment Videos

Last Updated: Jan 29, 2026

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

1.3K
TChIP-Seq: Cell-Type-Specific Epigenome Profiling
07:28

TChIP-Seq: Cell-Type-Specific Epigenome Profiling

Published on: January 23, 2019

8.4K
Integrate Imaging Flow Cytometry and Transcriptomic Profiling to Evaluate Altered Endocytic CD1d Trafficking
09:01

Integrate Imaging Flow Cytometry and Transcriptomic Profiling to Evaluate Altered Endocytic CD1d Trafficking

Published on: October 29, 2018

7.1K

Area of Science:

  • Endocrinology
  • Oncology
  • Epigenetics

Background:

  • Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors with varied clinical behavior and molecular causes.
  • Understanding the molecular drivers of PPGL heterogeneity and malignancy is crucial for improved classification and treatment.

Purpose of the Study:

  • To characterize DNA methylation and gene expression patterns in PPGLs.
  • To identify molecular differences between PPGL subtypes and malignant tumors.
  • To delineate cluster- and malignancy-specific epigenetic patterns using integrative analysis.

Main Methods:

  • Integrative analysis of DNA methylation (Illumina EPIC 850K) and gene expression (Affymetrix microarrays) in 24 PPGLs.
  • Comparison with The Cancer Genome Atlas (TCGA) data.
  • Differential methylation and gene expression analyses between tumor clusters and malignancy status.

Main Results:

  • Identified differentially methylated CpG sites distinguishing pseudohypoxic (Cluster I) and kinase-signaling (Cluster II) PPGLs, including a specific CpG in DSCAML1.
  • Found 101 differentially methylated CpGs between benign and malignant PPGLs, with notable changes in BAIAP2L1 and SHANK1.
  • Gene expression analysis revealed distinct transcriptional profiles in malignant tumors, involving RNA processing, metabolism, and adhesion pathways.

Conclusions:

  • Epigenetic modifications and transcriptional programs exhibit complex interplay in PPGLs, contributing to molecular heterogeneity.
  • Findings enhance understanding of PPGL tumor classification and identify potential biomarkers and therapeutic targets for malignant PPGLs.