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Cervical Artery Dissection in Autosomal Dominant Polycystic Kidney Disease
Anna Liu1, Helena Xeros1, Waseem Wahood2
1Department of Neurology, Mayo Clinic Rochester, 200 First St. SW, Rochester, MN 55905, USA.
Medicina (Kaunas, Lithuania)
|January 28, 2026
Summary
Cervical artery dissections (CeAD) are rare in autosomal dominant polycystic kidney disease (ADPKD) patients. However, conditions like stroke, aortic dissection, and hypertension increase the risk of CeAD in ADPKD.
Area of Science:
- Nephrology
- Vascular Neurology
- Cardiology
Background:
- Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder causing cysts in kidneys and other organs.
- While rare, cervical artery dissections (CeAD) have been observed in association with ADPKD.
- Understanding risk factors for CeAD in ADPKD is crucial for early detection and management.
Purpose of the Study:
- To identify clinical features in ADPKD patients that correlate with an increased likelihood of CeAD diagnosis.
- To analyze the prevalence and associated risk factors of CeAD in a large cohort of ADPKD patients.
Main Methods:
- Retrospective observational study using the National Inpatient Sample (2016-2020).
- Comparison of clinical features between patients with ADPKD, CeAD, and both diagnoses.
- Statistical analysis using Cochran-Armitage and Chi-square tests to identify risk factors.
Main Results:
- Out of 224,065 ADPKD patients, 155 (0.05%) also had CeAD.
- In ADPKD patients, acute ischemic stroke, transient ischemic attack, aortic dissection, coronary artery dissection, subarachnoid hemorrhage, coagulation defects, and hypertension were significant risk factors for CeAD.
- The cohort was predominantly white, with a mean age of 56.74 years.
Conclusions:
- CeAD is an uncommon complication in ADPKD patients.
- Specific comorbidities, including cerebrovascular events and aortic pathologies, are associated with a higher risk of CeAD in ADPKD.
- Identifying these risk factors can guide screening protocols for CeAD in ADPKD patients.
Keywords:
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