Related Experiment Video
Updated: Jan 29, 2026
09:24
3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
Published on: September 13, 2018
9.5K
Prognostic Significance of Hemogram Parameters in Non-Muscle Invasive Bladder Cancer: A Comprehensive Retrospective
Ali Nebioğlu1, Ahmet Turhan2, Mert Başaranoğlu2
1Urology Clinic, Mersin City Training and Research Hospital, Mersin 33240, Türkiye.
Medicina (Kaunas, Lithuania)
|January 28, 2026
Summary
Preoperative hemoglobin levels are key predictors of recurrence and progression in non-muscle-invasive bladder cancer (NMIBC). Lower hemoglobin indicates higher risk, suggesting its use in NMIBC risk stratification.
Area of Science:
- Urology
- Oncology
- Hematology
Background:
- Non-muscle-invasive bladder cancer (NMIBC) requires accurate risk stratification for effective management.
- Preoperative hematologic parameters are increasingly recognized for their prognostic potential.
Purpose of the Study:
- To assess the prognostic significance of preoperative complete blood count (CBC) parameters in NMIBC patients.
- To identify optimal cutoff values for CBC parameters.
- To explore integrating CBC parameters into existing NMIBC risk stratification systems.
Main Methods:
- Retrospective cohort study of 551 NMIBC patients.
- Analysis of CBC parameters obtained within 30 days pre-transurethral resection.
- Statistical methods included Kaplan-Meier analysis, Cox regression, and ROC curve analysis.
Main Results:
- Lower preoperative hemoglobin (11.8 vs. 13.2 g/dL) and higher lymphocyte counts were associated with recurrence.
- Hemoglobin was an independent predictor of recurrence (HR 0.75), with an AUC of 0.692.
- Age and carcinoma in situ were also independent predictors of recurrence.
Conclusions:
- Routine hematologic indices, especially hemoglobin, have independent prognostic value in NMIBC.
- Incorporating these parameters may improve personalized treatment strategies for NMIBC.
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