Study on the Enrichment Effect of Suillus luteus Polysaccharide on Intestinal Probiotics and the Immunomodulatory Activity
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View abstract on PubMed
Summary
This summary is machine-generated.Suillus luteus polysaccharide (SLP) shows potential as a functional food. It modulates gut microbiota, enhances immunity, and suppresses tumors by 53.14% in mice.
Area Of Science
- Mycology
- Biochemistry
- Immunology
Background
- Suillus luteus is a valued edible fungus with bioremediation potential.
- Limited research exists on its bioactive polysaccharides' structure and gut microbiota effects.
Purpose Of The Study
- To characterize Suillus luteus polysaccharide (SLP) structure.
- To investigate SLP's regulatory effects on gut microbiota metabolism in tumor-bearing mice.
Main Methods
- Hot water extraction of SLP.
- Structural determination of SLP (molecular weight, molar ratios, backbone/side chains).
- Administration of SLP to tumor-bearing mice and analysis of gut microbiota and immune responses.
Main Results
- SLP has a high molecular weight (approx. 1.90 × 10^6 Da) and a specific monosaccharide composition (Fuc:Man:Glc:Gal).
- SLP features a β-(1→4)-Manp backbone with specific side chains.
- SLP treatment enriched Lactobacillus and Odoribacter, altered glyoxylate and dicarboxylic acid metabolism, boosted CD4+ T cell immunity, and achieved a 53.14% tumor suppression rate.
Conclusions
- SLP possesses unique structural characteristics.
- SLP positively modulates gut microbiota and immune function in a tumor-bearing mouse model.
- SLP shows promise for development as a functional food ingredient.
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