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Transcriptomic Analysis of Fusarium verticillioides Across Different Cultivation Periods Reveals Dynamic Gene
Meng-Ling Deng1,2, Jun-Jun He2, Xin-Yan Xie2
1Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Microorganisms
|January 28, 2026
Summary
This study reveals the dynamic gene expression of Fusarium verticillioides over time, identifying key metabolic pathways and mycotoxin gene clusters. Findings offer insights into fungal development and potential intervention strategies.
Area of Science:
- Mycology
- Plant Pathology
- Genomics
Background:
- Fusarium verticillioides causes significant corn yield losses and produces harmful mycotoxins.
- Understanding its temporal transcriptional dynamics is crucial for managing its impact.
Purpose of the Study:
- To conduct a time-series transcriptomic analysis of F. verticillioides at key developmental stages.
- To identify differentially expressed genes and enriched pathways governing fungal progression.
Main Methods:
- Time-series transcriptomic analysis of F. verticillioides at 3, 5, 7, and 9 days post-inoculation.
- Gene Ontology enrichment and pathway analysis.
- Mfuzz clustering for expression trajectory delineation.
Main Results:
- Identified thousands of differentially expressed genes across cultivation stages.
- Enriched terms included 'integral component of membrane', 'amino acid metabolism', and 'carbohydrate metabolism'.
- Fumonisin and fusaric acid biosynthetic gene clusters showed coordinated early peak expression.
Conclusions:
- This study provides the first comprehensive temporal transcriptome of F. verticillioides.
- Reveals dynamic transcriptional networks essential for fungal adaptation.
- Highlights potential time-sensitive targets for intervention strategies against this pathogen.
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