Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Performing a Simple Data Analysis using MS-Excel Function01:17

Performing a Simple Data Analysis using MS-Excel Function

1.0K
Microsoft Excel offers a suite of functions and tools ideal for statistical analysis, making it accessible to students and researchers. This article outlines fundamental Excel functions pivotal for data analysis.
SUM: This function calculates the total sum of a range of values. It's the foundation for aggregating data, essential for determining overall trends and totals in datasets.
AVERAGE: It computes the mean value of a given set of numbers, providing a quick insight into the central...
1.0K
Pain01:20

Pain

1.4K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.4K
The Influence of Affect on Cognition01:29

The Influence of Affect on Cognition

277
Positive affect significantly influences cognitive processes, including evaluation, memory, creativity, and social judgments. Compared to negative affect, positive emotional states promote more favorable interpretations of stimuli, cognitive flexibility, and heuristic processing. These effects highlight emotions' powerful role in shaping how individuals perceive, remember, and interact with the world.Influence on Evaluation and AttributionWhen individuals experience positive affect, they are...
277
The Influence of Cognition on Affect01:29

The Influence of Cognition on Affect

200
Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
200
Bioavailability: Influencing Factors01:22

Bioavailability: Influencing Factors

366
Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
366
Analgesia and Pain Management01:25

Analgesia and Pain Management

1.6K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reproducibility of a Shear Wave Elastography Procedure for Assessing the Piriformis Muscle Stiffness in a Sample of Healthy Young Adults Under Controlled Laboratory Conditions: An Intra- and Inter-Examiner Reliability Study.

Journal of clinical medicine·2026
Same author

The Influence of Catechol-O-Methyltransferase Val158Met Polymorphism in Cognitive Performance and Executive Functioning in Women with Migraine.

Journal of clinical medicine·2026
Same author

Influence of Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism in Conditioned Pain Modulation in Women with Migraine.

International journal of molecular sciences·2026
Same author

Migraine Features and Nociceptive Profile Do Not Influence Conditioned Pain Modulation in Women With Episodic and Chronic Migraine.

Pain research & management·2026
Same author

Frequency and severity of adverse events associated with dry needling: a systematic review and meta-analysis.

Physical therapy·2026
Same author

Pressure Pain Threshold Cut-Off Points at Trigeminal and Extra-Trigeminal Nervous and Musculoskeletal Structures to Discriminate Patients with Migraine from Episodic Tension-Type Headache: A Diagnostic Accuracy Study.

Diagnostics (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jan 29, 2026

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
12:29

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions

Published on: May 23, 2011

20.0K

Neurocognitive Performance and Executive Functions Do Not Influence Conditioned Pain Modulation in Women with

Juan C Pacho-Hernández1, Angela Tejera-Alonso2, Ana I de-la-Llave-Rincón3

  • 1Department of Research and Psychology in Education, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Life (Basel, Switzerland)
|January 28, 2026
PubMed
Summary

Women with migraine exhibit impaired conditioned pain modulation (CPM), particularly for mechanical pain, unlike pain-free individuals. Cognitive functions did not influence this pain modulation deficit in migraineurs.

Keywords:
attentionconditioned pain modulationmemorymigraineprocessing

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.7K
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.9K

Related Experiment Videos

Last Updated: Jan 29, 2026

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
12:29

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions

Published on: May 23, 2011

20.0K
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.7K
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.9K

Area of Science:

  • Neuroscience
  • Pain Research
  • Clinical Psychology

Background:

  • Migraine is characterized by altered pain processing and cognitive deficits.
  • Descending pain modulation, including conditioned pain modulation (CPM), is crucial for pain control.
  • The role of neurocognitive and executive functions in CPM in migraine remains unexplored.

Purpose of the Study:

  • To investigate the influence of neurocognitive processes and executive functions on CPM in women with migraine.
  • To compare CPM activation between women with migraine and healthy controls.

Main Methods:

  • A case-control study involving 140 women with migraine and 70 controls.
  • Assessment of clinical migraine features, neurocognitive functions (attention), and executive functions (memory, inhibition, processing speed).
  • Evaluation of CPM using the cold pressor test paradigm, measuring changes in mechanical and thermal pain thresholds.

Main Results:

  • Women with migraine showed deficits in CPM, with decreased pressure pain thresholds (PPTs) after a conditioned stimulus, unlike controls who showed increased PPTs.
  • These CPM deficits were significant for mechanical stimuli at the temporalis, lateral epicondyle, and tibialis anterior muscles.
  • No significant modulation of CPM by neurocognitive processes or executive functions was observed in women with migraine.

Conclusions:

  • Women with episodic or chronic migraine demonstrate impaired CPM, especially for mechanical pain, compared to pain-free individuals.
  • Neurocognitive and executive functions do not appear to modulate CPM activity in women with migraine.
  • Findings highlight a potential mechanism for altered pain processing in migraine.