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Updated: Jan 29, 2026
05:53
An Effective Mouse Model of Unilateral Renal Ischemia-Reperfusion Injury
Published on: July 15, 2021
8.2K
High-Intensity Interval Training Attenuates Inflammation in Cardiorenal Syndrome Induced by Renal
Po-Chien Tsao1, Chang-Chi Lai2, Szu-Kai Fu2
1Graduate Institute of Sports Training, University of Taipei, Taipei 11153, Taiwan.
Life (Basel, Switzerland)
|January 28, 2026
Summary
High-intensity interval training (HIIT) partially protects against cardiac injury following acute kidney injury (AKI) by reducing inflammation. Further research is needed to confirm HIIT as a preconditioning strategy.
Area of Science:
- Cardiovascular Science
- Nephrology
- Exercise Physiology
Background:
- Acute kidney injury (AKI) is a common complication of renal and cardiovascular procedures.
- AKI can trigger systemic inflammation, leading to secondary cardiac injury.
- The potential protective effects of exercise preconditioning against AKI-induced cardiac damage are not fully understood.
Purpose of the Study:
- To investigate the efficacy of high-intensity interval training (HIIT) as a preconditioning strategy against renal ischemia-reperfusion (I/R)-induced cardiac injury.
- To assess the impact of HIIT on biochemical and histological markers of renal and cardiac damage.
- To explore the underlying mechanisms, particularly the modulation of systemic inflammation.
Main Methods:
- Thirty male Sprague-Dawley rats were divided into three groups: Sham, Renal I/R, and HIIT followed by Renal I/R.
- Biochemical markers (creatinine, CK, troponin I, LDH, inflammatory cytokines) and histological assessments of renal and cardiac tissues were performed.
- Cardiac injury was evaluated using myocardial injury scoring, TUNEL staining, and assessment of apoptosis-related proteins (caspase-3, Bax) and TNF-α.
Main Results:
- Renal I/R induced significant renal dysfunction, systemic inflammation, and myocardial damage.
- Prior HIIT intervention significantly attenuated increases in creatinine, CK, troponin I, and LDH.
- HIIT also reduced levels of inflammatory cytokines and key markers of cardiac apoptosis and inflammation (caspase-3, TNF-α).
Conclusions:
- High-intensity interval training (HIIT) offers partial protection against renal I/R-induced systemic inflammation and cardiac injury.
- The protective effects of HIIT appear to be mediated, at least in part, by the attenuation of inflammatory pathways.
- HIIT may represent a potential preconditioning strategy, but further investigation is warranted to establish its definitive role.
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