Related Experiment Video
Updated: Jan 29, 2026

Isolation and Culture of Primary Human Gingival Epithelial Cells using Y-27632
Published on: November 6, 2021
Gingival Thickness Improvement After Atelocollagen Injection-Retrospective Study
Sylwia Klewin-Steinböck1, Anna Duda-Sobczak2, Marzena Liliana Wyganowska1
1Department of Periodontology and Oral Mucosa Diseases, Poznan University of Medical Science, 70 Bukowska St., 60-812 Poznan, Poland.
Injectable atelocollagen effectively increases gingival thickness. Maintenance therapy ensures sustained results, while its absence leads to a gradual decrease in effectiveness over five years.
Area of Science:
- Periodontology
- Regenerative Medicine
- Biomaterials
Background:
- Gingival thickness is crucial for periodontal health and aesthetics.
- Thin gingival phenotype poses challenges in dental treatments.
- Injectable atelocollagen offers a potential solution for gingival augmentation.
Purpose of the Study:
- To evaluate the long-term efficacy of injectable atelocollagen in increasing gingival thickness.
- To compare the outcomes of atelocollagen treatment with and without maintenance therapy.
- To assess the stability of gingival thickness changes over a five-year period.
Main Methods:
- Retrospective analysis of 60 patients with thin gingival phenotype.
- Standardized atelocollagen injections for soft tissue modification.
- Division into two groups: with (Group A) and without (Group B) maintenance therapy.
- Five-year observation period with gingival thickness assessment using periodontal probes.
- Statistical analysis using linear and generalized linear mixed-effects models.
Main Results:
- Significant Group and Time interaction effects on gingival thickness were observed.
- Group A demonstrated sustained gingival thickness improvement over five years.
- Group B showed a gradual decrease in gingival thickness effectiveness post-treatment.
- Atelocollagen injections led to a significant increase in the proportion of sites with thick gingiva.
Conclusions:
- Injectable atelocollagen is a reliable and effective method for long-term gingival thickness modification.
- Maintenance therapy is essential for sustaining the benefits of atelocollagen treatment.
- Atelocollagen offers a user-friendly approach to enhance gingival biotype.
Related Concept Videos
Design Example: Deciding Thickness of Lubricating Fluid in a Shaft
To calculate the required thickness of the lubricant layer, the tangential velocity at the shaft's surface must first be determined. This velocity is calculated by converting the rotational speed to angular velocity...
Improving Translational Accuracy
Improving Translational Accuracy
Case Studies
Gas Chromatography: Sample Injection Systems
Two primary injection methods are used...
Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection
Following the administration of a single intravenous (IV) bolus injection, we can determine the concentration of the drug in the plasma at any given time. This calculation is achieved using a specific equation that integrates the values of Vmax and KM.
We can also...

