Visual Large Language Models in Radiology: A Systematic Multimodel Evaluation of Diagnostic Accuracy and...

Visual large language models (VLLMs) are discussed as potential tools for assisting radiologists in image interpretation, yet their clinical value remains unclear. This study provides a systematic and comprehensive comparison of general-purpose and biomedical VLLMs in radiology. We evaluated 180 representative clinical images with validated reference diagnoses (radiography, CT, MRI; 60 each) using seven VLLMs (ChatGPT-4o, Gemini 2.0, Claude Sonnet 3.7, Perplexity AI, Google Vision AI, LLaVA-1.6, LLaVA-Med-v1.5). Each model interpreted the image without and with clinical context. Mixed-effects logistic regression models assessed the influence of model, modality, and context on diagnostic performance and hallucinations (fabricated findings or misidentifications). Diagnostic accuracy varied significantly across all dimensions (p ≤ 0.001), ranging from 8.1% to 29.2% across models, with Gemini 2.0 performing best and LLaVA performing weakest. CT achieved the best overall accuracy (20.7%), followed by radiography (17.3%) and MRI (13.9%). Clinical context improved accuracy from 10.6% to 24.0% (p < 0.001) but shifted the model to rely more on textual information. Hallucinations were frequent (74.4% overall) and model-dependent (51.7-82.8% across models; p ≤ 0.004). Current VLLMs remain diagnostically unreliable, heavily context-biased, and prone to generating false findings, which limits their clinical suitability. Domain-specific training and rigorous validation are required before clinical integration can be considered.