Related Experiment Video
Updated: Jan 29, 2026
07:42
Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients
Published on: February 7, 2021
5.7K
Predictive Value of Apelin-36 for No-Reflow Phenomenon in STEMI Patients
Xhevdet Krasniqi1,2, Xhevat Jakupi1, Josip Vincelj3
1Department of Internal Medicine, Medical Faculty, University of Prishtina "Hasan Prishtina", 10000 Prishtina, Kosovo.
Life (Basel, Switzerland)
|January 28, 2026
Summary
Serum apelin-36 levels are associated with the no-reflow phenomenon in ST-segment elevation myocardial infarction (STEMI) patients. A cut-off value of 0.58 ng/mL can identify patients at increased risk of no-reflow after primary percutaneous coronary intervention.
Area of Science:
- Cardiology
- Biochemistry
- Medical Diagnostics
Background:
- Apelin is upregulated in ST-segment elevation myocardial infarction (STEMI) and offers cardioprotection against ischemia-reperfusion injury (IRI).
- Investigating serum apelin-36 levels in STEMI patients is crucial for understanding its role in the no-reflow phenomenon.
Purpose of the Study:
- To examine serum apelin-36 levels in STEMI patients.
- To determine the relationship between serum apelin-36 levels and the incidence of the no-reflow phenomenon post-primary percutaneous coronary intervention (pPCI).
Main Methods:
- 161 STEMI patients undergoing pPCI within 12 hours of symptom onset were enrolled.
- Serum apelin-36, troponin T, and other biochemical markers were measured.
- Echocardiography was performed, and patients were grouped based on apelin-36 levels.
Main Results:
- A higher incidence of no-reflow phenomenon was observed in patients with apelin-36 levels > 0.58 ng/mL (47.82%) compared to those with levels ≤ 0.58 ng/mL (25.21%).
- A positive correlation was found between apelin-36 levels and the Gensini score.
- Apelin-36 and diabetes mellitus were identified as significant predictors of no-reflow, with a diagnostic cut-off value of 0.58 ng/mL (AUC = 0.77).
Conclusions:
- Serum apelin-36 levels are significantly associated with the no-reflow phenomenon in STEMI patients.
- An admission apelin-36 cut-off value of 0.58 ng/mL can aid in identifying STEMI patients at higher risk for no-reflow/reperfusion injury.
More Related Videos
Related Concept Videos
01:10Tip-of-the-Tongue Phenomenon
516
The tip-of-the-tongue (TOT) phenomenon is a cognitive experience characterized by a temporary inability to retrieve specific information from memory despite having a strong feeling of knowing the information. Although individuals cannot access the target word or detail, they frequently recall related elements, such as its initial letter, syllable count, or context. This partial retrieval often causes frustration, as one might recognize a familiar face or know that a name starts with a specific...
516
02:27Predicting Molecular Geometry
45.7K
VSEPR Theory for Determination of Electron Pair Geometries
45.7K
01:03Prediction Intervals
3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
3.4K
01:07End Point Prediction: Gran Plot
1.2K
A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
For potentiometric titration, the Gran plot is created by plotting...
For potentiometric titration, the Gran plot is created by plotting...
1.2K
01:13Sensitivity, Specificity, and Predicted Value
1.3K
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
Sensitivity is the...
1.3K
02:24Predicting Reaction Outcomes
10.8K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K