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Socioemotional Development during Infancy01:30

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Correction: Yalçın et al. Impact of SGLT2 Inhibitors on Cardiovascular Risk Scores, Metabolic Parameters, and Laboratory Profiles in Type 2 Diabetes. <i>Life</i> 2025, <i>15</i>, 722.

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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
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Miscarriage Tissue Research: Still in Its Infancy.

Rosa E Lagerwerf1, Laura Kox2, Melek Rousian3

  • 1Department of Obstetrics and Gynaecology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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Summary
This summary is machine-generated.

Millions of miscarriages annually remain unexplained. Genetic analysis and imaging of products of conception (POC) show promise but require further research before routine clinical use.

Keywords:
genetic analysiskaryotypingmicro-CTmiscarriagepost-mortem imagingpregnancy loss

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Area of Science:

  • Reproductive Medicine
  • Genetics
  • Medical Imaging

Background:

  • Miscarriage affects millions globally, causing emotional distress and economic loss.
  • Current investigations focus on recurrent cases and maternal factors, leaving over 90% of miscarriages unexplained.
  • Routine genetic analysis of pregnancy tissue is not advised due to unclear clinical impact.

Purpose of the Study:

  • To review genetic analysis, autopsy, and imaging techniques for products of conception (POC).
  • To evaluate the diagnostic potential and cost-effectiveness of various methods for unexplained miscarriages.

Main Methods:

  • Narrative review of genetic analyses (Karyotyping, QF-PCR, SNP array, aCGH).
  • Review of post-mortem imaging techniques (PMUS, UHF-MRI, micro-CT).
  • Assessment of technical success rates and cost-effectiveness.

Main Results:

  • QF-PCR demonstrated the highest technical success rate and cost-effectiveness among genetic methods.
  • Micro-CT showed the highest cost-effective performance among imaging techniques.
  • Karyotyping was the least promising method for POC examination.

Conclusions:

  • Current guidelines leave most miscarriages unexplained.
  • Genetic and imaging techniques show diagnostic potential but need further evaluation in research settings.
  • Future research should assess diagnostic, psychosocial, and economic outcomes before clinical implementation.