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Updated: Jan 29, 2026
08:04
Murine Fetal Echocardiography
Published on: February 15, 2013
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From Diagnosis to Decision-Fetal Limb Abnormalities.
Andreea Florentina Stancioi-Cismaru1,2,3, Razvan Grigoras Capitanescu1,2, Mihaela-Simona Naidin4
18th Department, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Journal of Clinical Medicine
|January 28, 2026
Summary
Prenatal ultrasound (US) achieves 85.5% diagnostic accuracy for fetal limb abnormalities. Operator expertise significantly impacts accuracy, more than technical factors or gestational age at scan.
Area of Science:
- Medical Imaging
- Obstetrics & Gynecology
- Pediatric Orthopedics
Background:
- Prenatal ultrasound (US) is crucial for detecting fetal abnormalities.
- Fetal limb abnormalities represent a significant category of congenital anomalies.
Purpose of the Study:
- To evaluate the diagnostic accuracy of prenatal US for fetal limb abnormalities.
- To identify predictors of diagnostic accuracy, including operator expertise and technical parameters.
Main Methods:
- Prospective enrollment of cases undergoing routine prenatal US across five centers.
- Analysis of cases with suspected, diagnosed, or missed limb abnormalities.
- Statistical analysis including Fisher's exact test, Chi-square, Spearman's correlation, and ROC curve analysis.
Main Results:
- Overall diagnostic accuracy for fetal limb abnormalities was 85.5%.
- Operator expertise was the strongest predictor of diagnostic accuracy.
- Technical parameters like scan duration and equipment type did not significantly predict accuracy.
Conclusions:
- Prenatal US demonstrates high diagnostic accuracy for fetal limb abnormalities.
- Operator expertise and training are paramount for accurate prenatal diagnosis of limb anomalies.
- Focusing on operator skill development may enhance diagnostic performance more than technical advancements.
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