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Dual Core-Shell Loaded Lipid-Polymer Hybrid Nanoparticles as Combination Anti-Infective Delivery Platforms.

Valeria Carini1, Giulia Scagnetti1, Joanne Foulkes1

  • 1School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK.

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Summary
This summary is machine-generated.

This study demonstrates novel lipid-polymer hybrid nanoparticles (LPHNPs) for dual drug delivery. These nanoparticles effectively co-encapsulate antibiotics and antimicrobial peptides, showing promise for combination anti-infective therapy.

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Area of Science:

  • Nanotechnology
  • Pharmaceutical Sciences
  • Infectious Diseases

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat, necessitating novel anti-infective agents and advanced drug delivery systems.
  • Innovative formulations are crucial for enhancing the efficacy of existing and new anti-infective compounds.

Purpose of the Study:

  • To demonstrate the feasibility of creating lipid-polymer hybrid nanoparticles (LPHNPs) with a core-shell structure for dual loading of anti-infectives.
  • To co-encapsulate the antibiotic cefotaxime and the antimicrobial peptide RN7IN6 within LPHNPs for combination therapy.

Main Methods:

  • LPHNPs were fabricated using microfluidic mixing, incorporating cefotaxime in a chitosan core and RN7IN6 in a lipid shell.
  • Particle characteristics and loading efficiency were optimized by adjusting flow rates and lipid concentration.
  • Minimum inhibitory concentrations (MICs) were assessed to evaluate preliminary antibacterial efficacy.

Main Results:

  • Uniformly nanosized LPHNPs were successfully produced with maximized core and shell loading of cefotaxime and RN7IN6, respectively.
  • Co-loaded LPHNPs exhibited enhanced antibacterial activity against *Escherichia coli*, with RN7IN6 potentiating cefotaxime's efficacy.
  • Empty LPHNPs also demonstrated notable antibacterial effects, particularly against Gram-negative bacteria.

Conclusions:

  • The study successfully established the feasibility of core-shell LPHNPs for co-delivering multiple anti-infective agents.
  • The promising antibacterial efficacy of these co-loaded LPHNPs suggests their potential as advanced combination therapy platforms.
  • Further research is warranted to explore the full therapeutic potential of these LPHNPs in combating antimicrobial resistance.