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Three-Dimensional In Vitro Biomimetic Model of Neuroblastoma Using Collagen-Based Scaffolds
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Development and Evaluation of Scaffolds Based on Perch Collagen-Hydroxyapatite for Advanced Synthetic Bone
Alina Elena Coman1, Ana Maria Rosca2, Maria Minodora Marin3
1Collagen Department, Division Leather and Footwear Research Institute, National Research and Development Institute for Textiles and Leather, 93 Ion Minulescu St., 031215 Bucharest, Romania.
Pharmaceutics
|January 28, 2026
Summary
New perch collagen-hydroxyapatite scaffolds show promise for bone tissue engineering. These materials offer structural stability, controlled degradation, and support cell growth, making them viable for bone defect repair.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Materials Science
Background:
- Bone defects represent a significant clinical challenge, necessitating advanced regenerative strategies.
- Type I collagen-hydroxyapatite composites mimic natural bone matrix, ideal for bone tissue engineering.
- Marine collagen provides a sustainable and cost-effective alternative for biomaterial development.
Purpose of the Study:
- To develop and characterize perch collagen-hydroxyapatite scaffolds for bone tissue engineering applications.
- To evaluate the mechanical, biological, and degradation properties of these novel composite scaffolds.
Main Methods:
- Composite scaffolds were fabricated with varying collagen:hydroxyapatite (COLL:HAp) ratios (100:0, 50:50, 40:60, 30:70).
- Characterization included Fourier-transform infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), X-ray Energy Dispersive Spectroscopy (X-EDS), compression testing, cell viability assays, and degradation studies.
- Porosity, water absorption, thermal stability, and antimicrobial activity were also assessed.
Main Results:
- FT-IR confirmed successful composite formation. SEM revealed interconnected porous structures with uniform hydroxyapatite distribution.
- Scaffolds exhibited increasing stiffness with higher hydroxyapatite content, demonstrating mechanical resistance.
- Enhanced osteoblast viability and colonization were observed, alongside gradual biodegradation and moderate antimicrobial activity.
Conclusions:
- Perch collagen-hydroxyapatite composites offer a promising combination of structural integrity, tunable mechanical properties, and biocompatibility for bone tissue engineering.
- These scaffolds represent a viable biomaterial for addressing bone defects, particularly in non-load-bearing applications.
- The use of marine collagen presents a sustainable approach to developing advanced bone regenerative materials.
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