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In Vitro Permeation of FITC-loaded Ferritins Across a Rat Blood-brain Barrier: a Model to Study the Delivery of Nanoformulated Molecules
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Quality by Design for the Nanoformulation of Cosmeceuticals
Gerardo Leyva-Gómez1, Elizabeth Piñón-Segundo2, Zaida Urban-Morlan3
1Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
Pharmaceutics
|January 28, 2026
Summary
Quality by Design (QbD) enhances nanocosmeceutical development by ensuring safety and efficacy. This approach optimizes the use of nanocarriers for improved bioactive delivery and product performance.
Area of Science:
- Dermatology and Pharmaceutical Sciences
- Nanotechnology in Cosmetics
Background:
- Cosmeceuticals offer biological benefits beyond traditional cosmetics.
- Bioactive compounds in cosmeceuticals often face challenges with transdermal delivery.
- Nanocarriers show potential for enhancing the efficacy of cosmeceutical formulations.
Purpose of the Study:
- To review the implementation of Quality by Design (QbD) in nanocosmeceutical development.
- To analyze the characteristics of bioactive groups and nanocarriers for topical and transdermal applications.
- To highlight the importance of QbD for ensuring nanocosmeceutical safety and efficacy.
Main Methods:
- Literature review focusing on QbD principles applied to nanocosmeceuticals.
- Analysis of common bioactive molecules and nanocarrier systems used in cosmeceutical formulations.
- Examination of safety and efficacy verification strategies in nanocosmeceutical development.
Main Results:
- QbD provides a systematic framework for developing sophisticated nanocosmeceuticals.
- Nanocarriers significantly improve the transdermal passage and effectiveness of cosmeceutical bioactives.
- Integration of QbD ensures that nanocosmeceuticals meet consumer needs and regulatory standards.
Conclusions:
- QbD is crucial for the successful development and commercialization of safe and effective nanocosmeceuticals.
- Understanding bioactive properties and nanocarrier behavior is key to optimizing formulations.
- The review underscores the need for rigorous development approaches in advanced cosmetic science.
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