Laser-Based QR Code Marking on Double Film-Coated Tablets: Balancing Marking Efficiency and Tablet Integrity-A Step...

Area of Science:

• Pharmaceutical technology
• Laser processing
• Drug delivery systems

Background:

• Laser marking is vital in the pharmaceutical industry for solid dosage forms (SDFs).
• Combating falsified medicines requires innovative anti-counterfeiting measures beyond packaging serialization.
• Directly marking tablets with QR codes offers a potential solution to enhance traceability.

Purpose of the Study:

• To evaluate QR code marking on double film-coated ibuprofen tablets using an ultrafast laser.
• To assess the impact of laser marking on the functional integrity and drug release of the tablets.
• To determine the feasibility of laser-based QR code marking at industrially relevant speeds.

Main Methods:

• Tablets were coated with gastro-resistant and immediate-release layers (TiO2-containing and TiO2-free).
• QR codes were ablated using an ultrafast Ti:Sa laser with varied parameters.
• Physical, chemical, and microscopic analyses, including SEM, Raman, and in vitro dissolution, were performed.

Main Results:

• No significant differences were found between TiO2-containing and TiO2-free coatings.
• QR code readability was dependent on laser settings and coating type.
• The laser achieved high-speed, high-precision marking, potentially economically viable.
• Ablation depth could be managed with appropriate coating thickness to maintain desired drug release.

Conclusions:

• Ultrafast laser QR code marking on dosage forms presents significant benefits for healthcare and drug traceability.
• Potential undesirable effects on dosage form behavior necessitate careful formulation and laser parameter selection.
• Particular attention is required for delayed-release (DR) systems to ensure functional integrity.