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Mulberry Leaf-Derived Bioactive Constituents on Diabetes: Structure, Extraction, Quality Analysis, and Hypoglycemic
Siyue Zhou1, Yidong Xu1, Yehao Lin1
1Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin 300072, China.
Molecules (Basel, Switzerland)
|January 28, 2026
Summary
Mulberry leaf shows promise for managing diabetes by lowering blood sugar. Further research is needed to develop new diabetes drugs from mulberry leaf compounds and optimize extraction methods.
Area of Science:
- Phytochemistry
- Pharmacology
- Metabolic Disorders
Background:
- Diabetes mellitus is a growing global health concern.
- Mulberry leaf (ML) is a traditional remedy with known blood sugar-lowering properties.
- Existing research on ML's hypoglycemic potential requires systematic consolidation.
Purpose of the Study:
- To systematically review ML's hypoglycemic constituents.
- To analyze extraction, quality control, and mechanisms of action.
- To guide future research and drug development for diabetes.
Main Methods:
- Systematic literature review following PRISMA 2020 guidelines.
- Searched Web of Science and PubMed databases (2015-2025).
- Evaluated conventional and modern extraction techniques (UAE, MAE, EAE).
Main Results:
- Reviewed various extraction methods for ML, noting advantages and limitations.
- Examined analytical techniques for quality control of ML and its compounds.
- Summarized hypoglycemic mechanisms: antioxidant, insulin resistance improvement, enzyme regulation, gut microbiota modulation.
Conclusions:
- Mulberry leaf exhibits significant potential for diabetes treatment.
- Further research is essential for novel drug discovery from ML.
- Efficient extraction, quality analysis, and mechanistic studies are crucial.
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