Related Experiment Video
Updated: Jan 29, 2026

Time-resolved ElectroSpray Ionization Hydrogen-deuterium Exchange Mass Spectrometry for Studying Protein Structure and Dynamics
Published on: April 17, 2017
Computational Analysis of the Asymmetric Hydrogenation of γ-Ketoacids: Weak Interactions and Kinetics
Ivan S Golovanov1, Evgeny V Pospelov1
1N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.
Abstract:
A computational study of the mechanism of asymmetric hydrogenation of γ-keto acids with the Ni(S,S)-QuinoxP* system was conducted. The main steps of the reaction mechanism were determined, including the formation of the NiH(S,S-QuinoxP*)+ complex starting from a γ-keto acid molecule and the involvement of the hydrogen "metathesis" step. The rate-limiting and stereo-determining step of the reaction was identified as the transfer of a hydrogen atom from the catalytic particle to the carbonyl group of the substrate molecule. The stereochemical outcome of the process was calculated. The influence of weak interactions on the stereoselectivity of the process was demonstrated using NCI and sobEDAw analyses.
More Related Videos
14:11Quantification of Hydrogen Concentrations in Surface and Interface Layers and Bulk Materials through Depth Profiling with Nuclear Reaction Analysis
Published on: March 29, 2016
08:19Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
Published on: January 15, 2016
Related Concept Videos
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Hydrogen Bonds
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....
Weak Base Solutions
Weak Acid Solutions
Titration of a Weak Acid with a Weak Base
As a result, there is no simple...
Titration Calculations: Weak Acid - Strong Base
For the titration of 25.00 mL of 0.100 M CH3CO2H with 0.100 M NaOH, the reaction can be represented as: