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Updated: Jan 29, 2026
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Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
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Capric Acid-Based Therapeutic Deep Eutectic Systems: A Focused Review Within the Framework of Deep Eutectic Solvents
Faisal Al-Akayleh1, Ahmed S A Ali Agha2, Ali R Olaimat3
1Faculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.
Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
Summary
Capric acid (CA)-based therapeutic deep eutectic systems (THEDES) enhance drug solubility, permeability, and bioactivity. These green formulations offer a novel platform for drug delivery, though stability and regulatory aspects require further investigation.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Drug Delivery Systems
Background:
- Capric acid (CA)-based therapeutic deep eutectic systems (THEDES) are novel biofunctional matrices.
- These systems show potential for improving drug solubilization, permeability, and bioactivity.
Purpose of the Study:
- To review and synthesize evidence on the design, mechanisms, and pharmaceutical performance of CA-THEDES.
- To identify unifying principles and future research directions for CA-THEDES.
Main Methods:
- Targeted database searches were conducted to identify relevant studies on CA-THEDES.
- Screening of identified studies focused on their design, mechanisms, and pharmaceutical performance.
Main Results:
- CA-THEDES enhance drug solubility through hydrogen bonding and amorphization.
- Improved transdermal and transmucosal permeation is observed due to CA's amphiphilic chain.
- CA exhibits synergistic antimicrobial and anticancer effects, acting as a co-therapeutic.
- Gaps identified in long-term stability, toxicology, and regulatory classification.
Conclusions:
- CA-THEDES offer a rationally designable platform for next-generation drug delivery.
- These systems integrate solvent functionality with therapeutic activity in a single green formulation.
- AI/ML approaches can aid in rational selection and optimization of CA-THEDES.
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