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Updated: Jan 29, 2026
06:17
Measuring the Strength of Mice
Published on: June 2, 2013
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Manganese Exposure Is Associated with Reduced Grip Strength: Evidence from Humans and Mice
Peiyu Fang1,2, Chuanqiao Tang1,2, Shengtao Wei1,2
1Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Toxics
|January 28, 2026
Summary
Environmental manganese exposure is linked to reduced grip strength in elderly men. Animal studies suggest this may be due to inflammation in muscle tissue, even at lower exposure levels.
Area of Science:
- Environmental Health
- Neurotoxicology
- Gerontology
Background:
- Excessive manganese (Mn) exposure is known to cause neuromotor deficits.
- The impact of environmental manganese levels on grip strength in older adults is not well understood.
Purpose of the Study:
- To investigate the association between environmental manganese exposure and grip strength in elderly men.
- To explore potential mechanisms, including muscle inflammation, using animal models.
Main Methods:
- A cross-sectional study of 375 elderly men (60-74 years) in China, measuring urinary manganese and grip strength.
- Generalized linear models and restricted cubic splines were used for statistical analysis.
- Animal experiments involved exposing mice to varying doses of manganese chloride and measuring grip strength and inflammatory markers (CRP, IL-6, TNF-α) in muscle tissue.
Main Results:
- Urinary manganese was inversely associated with hand grip strength in elderly men after adjusting for confounders (p-trend = 0.007).
- Mice exposed to manganese showed a significant decline in grip strength with increasing exposure (p-trend < 0.0001).
- Manganese exposure in mice led to increased mRNA levels of inflammatory markers (CRP, IL-6, TNF-α) in muscle tissue.
Conclusions:
- Environmental manganese exposure is inversely associated with grip strength in elderly men.
- Findings suggest that reduced grip strength may be linked to muscle inflammation, a potential consequence of manganese exposure.
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