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Transmissible Gastroenteritis Virus Binding to Red Blood Cells Disrupts Iron Homeostasis and Promotes Viral Infection
Lu Xia1,2, Ziqi Wang1,2, Yeqing He1,2
1College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China.
Veterinary Sciences
|January 28, 2026
Summary
Transmissible gastroenteritis virus (TGEV) infects red blood cells (RBCs), impairing their function and oxygen transport. This RBC involvement in TGEV infection offers new diagnostic and therapeutic targets.
Area of Science:
- Veterinary Virology
- Hematology
- Pathophysiology
Background:
- Red blood cells (RBCs) are critical for oxygen transport.
- The effect of transmissible gastroenteritis virus (TGEV) on RBCs is not well understood.
- Investigating TGEV's impact on RBCs is crucial for understanding disease progression.
Purpose of the Study:
- To investigate the interaction between TGEV and RBCs in infected piglets.
- To determine the functional consequences of TGEV binding to RBCs.
- To explore the role of RBCs in TGEV pathogenesis.
Main Methods:
- Hematological analysis of TGEV-infected piglets.
- Viral detection within RBCs.
- Assessment of RBC deformability and oxygen-carrying capacity.
- Evaluation of macrophage-mediated phagocytosis and serum iron levels.
Main Results:
- TGEV-infected piglets showed altered RBC indices and elevated pCO2.
- TGEV was detected within RBCs, binding but not replicating.
- TGEV-bound RBCs had reduced deformability and oxygen-carrying capacity.
- TGEV infection increased RBC phagocytosis and decreased serum iron.
Conclusions:
- RBCs are involved in TGEV infection progression.
- TGEV binding to RBCs impairs their function, potentially exacerbating the disease.
- Findings suggest novel diagnostic and therapeutic strategies targeting RBCs in TGEV infections.
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