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Updated: Jan 29, 2026
07:27
Transcriptome Analysis of Single Cells
Published on: April 25, 2011
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Transcriptomic Analysis Provides Molecular Insights into Skin Development in Dezhou Donkey Foals
Tong Li1, Honglei Qu2,3, Liyuan Wang1
1College of Agriculture and Biology, Liaocheng University, Liaocheng 252000, China.
Veterinary Sciences
|January 28, 2026
Summary
Skin maturation in Dezhou donkey foals involves significant gene expression changes, impacting barrier function and collagen synthesis. This study reveals key molecular pathways driving skin development from newborn to one-year-old stages.
Area of Science:
- Comparative genomics and mammalian skin development.
- Transcriptomics and molecular biology of equine skin.
- Developmental biology and veterinary science.
Background:
- Mammalian skin undergoes critical molecular transformations during early life.
- Understanding these changes is vital for developmental biology and veterinary applications.
- Dezhou donkeys provide a unique model for studying equine skin maturation.
Purpose of the Study:
- To investigate transcriptomic differences in Dezhou donkey foal skin between newborn (Y0) and one-year-old (Y1) stages.
- To identify key genes and signaling pathways involved in skin maturation.
- To provide insights into the molecular mechanisms of mammalian skin development.
Main Methods:
- RNA-sequencing (Illumina NovaSeq 6000) was performed on skin samples from 13 Dezhou donkeys (7 Y0, 6 Y1).
- Transcriptome analysis identified differentially expressed genes (DEGs) between age groups.
- Functional enrichment analysis (e.g., KEGG) was used to determine affected biological pathways.
Main Results:
- 9878 significantly differentially expressed genes (DEGs) were identified between Y0 and Y1 foals.
- Up-regulation of keratin (KRT1) and WNT signaling genes (WNT3-7, WNT10) observed in Y1 foals.
- Down-regulation of collagen genes (COL1A, COL4A, COL5AS) and TGF-β pathway components (TGFB2, TGFB3, BMP5) in Y1 foals.
Conclusions:
- Skin maturation in Dezhou donkeys involves enhanced barrier function and hair follicle development.
- Reduced collagen synthesis rates are characteristic of mature equine skin.
- Findings offer insights into mammalian skin development and potential veterinary applications.
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