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Updated: Jan 29, 2026

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
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Omicron KP.3 RBD-Containing Spike mRNA Vaccine Induces Broadly Neutralizing Antibodies with Protection Against

Xiaoqing Guan1, Hansam Cho1, Shengnan Qian1

  • 1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.

Vaccines
|January 28, 2026
PubMed
Summary

A novel mRNA vaccine targeting the Omicron-KP.3 receptor-binding domain (RBD) shows broad neutralization against Omicron subvariants. This vaccine demonstrated stability, potent immunogenicity, and protective efficacy in a mouse model against SARS-CoV-2 Omicron-KP.3.

Keywords:
COVID-19Omicron subvariantsSARS-CoV-2broadly neutralizing activitycoronavirusprotective efficacyreceptor-binding domain

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