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Related Experiment Video

Updated: Jan 29, 2026

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
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No Glymphatic Dysfunction in Trigeminal Neuralgia: A Preliminary Study.

Barış Genç1, Kerim Aslan1

  • 1Faculty of Medicine, Department of Radiology, Ondokuz Mayıs University, Samsun, Türkiye.

Brain and Behavior
|January 28, 2026
PubMed
Summary

Glymphatic dysfunction does not appear to contribute to trigeminal neuralgia (TN) or change after surgery. These findings suggest TN mechanisms are independent of glymphatic impairment, even with sleep issues.

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Area of Science:

  • Neuroscience
  • Neurosurgery
  • Radiology

Background:

  • Trigeminal neuralgia (TN) patients may experience glymphatic dysfunction due to headaches and sleep disturbances.
  • Investigating glymphatic function is crucial for understanding TN pathogenesis.

Purpose of the Study:

  • Compare glymphatic function in TN patients versus healthy controls.
  • Assess glymphatic function changes after microvascular decompression surgery.
  • Examine the relationship between glymphatic function and clinical TN parameters.

Main Methods:

  • Utilized data from the OpenNeuro dataset on chronic trigeminal neuralgia.
  • Calculated Diffusion Tensor Imaging-Albumin-Induced Pulmonary Hypertension (DTI-ALPS) index values.
  • Employed nonparametric tests and Spearman correlation for statistical analysis.

Main Results:

  • No significant differences in DTI-ALPS indices were found between TN patients and controls.
  • Microvascular decompression surgery did not significantly alter glymphatic function.
  • No correlations were observed between DTI-ALPS indices and clinical variables like disease duration or severity.

Conclusions:

  • Glymphatic dysfunction is unlikely to be a primary factor in trigeminal neuralgia pathogenesis.
  • Microvascular decompression surgery does not impact glymphatic clearance.
  • TN mechanisms may be independent of glymphatic impairment, despite associated sleep disturbances.