Hybrid Nanofibers for Multimodal Accelerated Wound Healing.

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Nanotechnology

Background:

• Wound healing is a complex process requiring advanced therapeutic strategies.
• Biodegradable polymers offer potential for effective wound dressings.
• Multifunctional materials are needed to address various aspects of wound repair.

Purpose of the Study:

• To develop multimodal hybrid nanofibers for accelerated wound healing.
• To incorporate anti-inflammatory, regenerative, and antimicrobial properties into nanofibers.
• To evaluate the efficacy of these nanofibers in promoting wound recovery.

Main Methods:

• Blend electrospinning of poly(L-lactide-co-ε-caprolactone) (PLCL), cellulose acetate (CA), and polyethylene oxide (PEO).
• Functionalization of nanofibers with dexamethasone, ascorbic acid, and hyperbranched polymers.
• Characterization using scanning electron microscopy, ATR-FTIR, TGA, contact angle, and zeta potential measurements.
• In vivo studies to assess wound healing acceleration.

Main Results:

• Successful fabrication of pristine and drug-loaded hybrid nanofibers with controlled diameters (0.8-1.2 µm) and high porosity (72-86%).
• Physicochemical characterization confirmed the material properties and successful drug incorporation.
• In vivo studies showed significant wound healing acceleration by day 11, with enhanced cell proliferation, granulation, and remodeling.

Conclusions:

• Multimodal hybrid nanofibers fabricated via blend electrospinning show significant potential as advanced wound dressings.
• The incorporation of anti-inflammatory, regenerative, and antimicrobial agents enhances therapeutic efficacy.
• Integrative strategies utilizing these nanofibers represent a promising approach for advanced wound care.