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Case Report: Prolonged DAWS in an RLS patient under severe relational stress
1Exoplanets in Transit: Identification and Characterization (ExoTIC) Research Group, Astrobiology Research Unit, University of Liège, Liège, Belgium.
Frontiers in Human Neuroscience
|January 28, 2026
Summary
Dopamine agonist withdrawal syndrome (DAWS) can occur in restless legs syndrome (RLS) patients even on low doses, with relational stress potentially worsening symptoms. This case highlights the need for assessing psychological factors in DAWS management.
Area of Science:
- Neuroscience
- Pharmacology
- Psychiatry
Background:
- Dopamine agonist withdrawal syndrome (DAWS) is a severe condition primarily seen in Parkinson's disease (PD), but increasingly recognized in restless legs syndrome (RLS).
- While DAWS is typically linked to high-dose dopamine agonists (DAs) in PD, rare cases occur in RLS patients on low-dose therapy (≤ 0.75 mg pramipexole equivalent).
- Psychological and relational stressors, alongside prior medication changes, may modulate DAWS severity via a kindling-like mechanism.
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