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Updated: Jan 29, 2026

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
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Clinical characteristics and outcomes in 50 children with autoimmune hepatitis: a retrospective study from a single

Yandi Yang1, Fan Yang2, Min Yang3

  • 1The 82nd Group Army Hospital of PLA, Baoding, Hebei, China.

Frontiers in Medicine
|January 28, 2026
PubMed

Insights

Most Chinese children with autoimmune hepatitis (AIH) survive with their native liver. Outcomes depend on cirrhosis at presentation, not immunosuppressive therapy type.

Area of Science:

  • Hepatology
  • Pediatric Gastroenterology
  • Immunology

Background:

  • Autoimmune hepatitis (AIH) is poorly understood in Chinese children.
  • This study addresses the lack of data on AIH in this specific demographic.

Purpose of the Study:

  • To investigate the clinical features of AIH in Chinese children.
  • To identify predictors of outcomes in this pediatric cohort.

Main Methods:

  • Retrospective review of 50 pediatric AIH cases (2015-2025) at a Beijing center.
  • Analysis of clinical presentation, treatment, and outcomes.

Main Results:

  • Type 1 AIH was most common (78.0%).
  • Cirrhosis (48.0%) and liver failure (22.0%) were frequent at presentation.
  • 85.4% survived with native livers; outcomes were independent of immunosuppressive drug choice.
  • Low serum albumin and decompensated cirrhosis predicted poorer outcomes.

Conclusions:

  • The majority of pediatric AIH patients in China achieve survival with native livers.
  • Disease outcome is primarily influenced by the severity of cirrhosis at presentation, rather than the specific immunosuppressive treatment regimen used.
Abstract

Keywords:
autoimmune hepatitischildrenoutcometreatmenttype

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