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Published on: September 27, 2017
Cinnamomum verum extract as a potential therapeutic for atopic dermatitis through reducing lipid peroxidation and
Min Jung Kim1, Mi Jin Jang2, Ju-Hye Yang3
1College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Background:
Oxidative stress and lipid peroxidation play crucial roles in the pathogenesis of atopic dermatitis (AD). Among the by-products of lipid peroxidation, 4-hydroxynonenal (4-HNE) is known to exacerbate inflammatory responses.
Methods:
This study investigated the potential of Cinnamomum verum J. Presl. [Lauraceae] extract (CVE) in mitigating oxidative stress and suppressing 4-HNE-mediated inflammatory pathways in an AD model. The antioxidant properties of CVE were evaluated through lipid peroxidation assays, reactive oxygen species (ROS) measurement, and cytokine profiling.
Results:
CVE treatment significantly reduced 4-HNE levels, decreased pro-inflammatory cytokine expression, and restored antioxidant enzyme activity.
Conclusion:
These findings suggest that CVE may serve as a natural therapeutic agent for managing oxidative stress and inflammation in AD.
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