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New insights into the association between cardiometabolic index with metabolic profile, nutritional status, and

Sylvia Ramuth1, Rafael Leite Carvalho1, Rafael Zappitelli Moscogliato1

  • 1Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo, Brazil.

Frontiers in Aging
|January 28, 2026
PubMed

Insights

The cardiometabolic index (CMI) is linked to inflammation in older adults, especially those with obesity. Higher CMI correlates with increased body mass index and pro-inflammatory markers, suggesting its role in cardiovascular risk assessment.

Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Metabolic Health

Background:

  • The cardiometabolic index (CMI) is a predictor of cardiovascular and metabolic diseases.
  • Its association with systemic inflammation in the elderly, particularly concerning obesity, requires further investigation.

Purpose of the Study:

  • To investigate the relationship between the cardiometabolic index (CMI) and systemic inflammatory status in older adults.
  • To explore the interplay between CMI, metabolic profile, body mass index (BMI), and inflammaging in the aged population, considering obesity status.

Main Methods:

  • A cross-sectional study involving 132 older adults (mean age 71.3 years).
  • Data collected included demographic, anthropometric, and blood parameters (glucose, lipids, inflammatory markers).
  • Participants were analyzed based on CMI levels and BMI (normal weight vs. obesity).

Main Results:

  • Higher CMI was associated with unfavorable metabolic profiles (lower HDL-c, higher BMI, cholesterol, triglycerides) and increased pro-inflammatory cytokines.
  • CMI showed a positive correlation with BMI and pro-inflammatory markers across all participants.
  • Obese older adults with higher CMI exhibited elevated levels of IL-1β, IL-6, IFN-γ, and TNF-α, particularly women.

Conclusions:

  • The cardiometabolic index (CMI) shows potential for cardiovascular risk assessment in older adults.
  • CMI is associated with a pro-inflammatory systemic status in the elderly, especially in those with obesity.
  • Findings highlight the link between CMI, obesity, and inflammation in aging populations.
Abstract

Keywords:
agingcardiometabolic indexcytokinesinflammationnutritional status

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