Related Experiment Video

Updated: Jan 29, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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Notch signaling pathway modulation by food functional ingredients: mechanisms, cancer and immunoregulation

Rong-Zu Nie1,2,3, Huo-Min Luo1,2,3, Ya-Ping Liu1,2,3

  • 1College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.

Frontiers in Cell and Developmental Biology
|January 28, 2026
PubMed

Insights

Functional food ingredients can regulate the Notch signaling pathway (NSP) to exert anti-cancer effects. This review explores how these compounds impact cancer, offering insights for future therapeutic applications.

Area of Science:

  • Oncology
  • Molecular Biology
  • Nutritional Science

Background:

  • The Notch signaling cascade (NSP) plays a critical role in normal physiology and is implicated in cancer initiation and progression.
  • Aberrant NSP activity is linked to diverse tumor cell behaviors, exhibiting both pro- and anti-cancer properties.
  • Understanding NSP's complex role is crucial for developing novel cancer therapies.

Purpose of the Study:

  • To comprehensively review the role of NSP in cancer.
  • To examine the regulatory mechanisms of food functional ingredients on NSP.
  • To evaluate the potential anti-cancer effects of these ingredients via NSP modulation.

Main Methods:

  • Review of existing literature on NSP in cancer.
  • Analysis of molecular mechanisms by which food functional ingredients interact with NSP.
  • Evaluation of *in vitro* and *in vivo* studies demonstrating anti-cancer effects.

Main Results:

  • Food functional ingredients (polyphenols, terpenoids, vitamins, etc.) modulate NSP through distinct molecular pathways.
  • *In vitro* studies show these ingredients impact cancer cell phenotypes.
  • *In vivo* experiments confirm efficacy in inhibiting tumor growth and metastasis.

Conclusions:

  • Food functional ingredients possess significant potential for cancer treatment by regulating NSP.
  • Further basic and clinical research is needed to elucidate detailed mechanisms and facilitate clinical application.
  • Targeting NSP with dietary compounds offers a promising avenue for cancer therapy.
Keywords:
anti-cancer mechanismcancer treatmentfood functional ingredientsimmunomodulationnotch signaling

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