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Synergistic Intra- and Inter-Nanozyme Electron Transfer through Interfacial Assembly for Enhanced Multi-Enzyme

Kun Lu1, Jizi Liu2, Xiaoyang Zhu1

  • 1Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 28, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a novel Prussian Blue composite nanozyme (PB C-NZ) design using interfacial assembly. The MoS2/PB nanocomposite enhances enzyme-like activity through optimized electron transfer and band modulation.

Keywords:
composite nanozymeelectron transfermolybdenum disulfideprussian blueredox

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Prussian Blue composite nanozymes (PB C-NZs) show promise in biomedical fields.
  • Designing PB C-NZs with optimized multi-enzyme activities and understanding their mechanisms are challenging.
  • Electron transfer and redox properties are crucial for nanozyme performance.

Purpose of the Study:

  • To develop a novel interfacial assembly strategy for MoS2/PB nanocomposites.
  • To enhance the enzyme-like activity of PB C-NZs through synergistic electron interactions.
  • To investigate the role of electron transfer and band modulation in nanozyme performance.

Main Methods:

  • Interfacial assembly of MoS2/PB nanocomposites.
  • Utilizing electron transfer and energy band structure modulation.
  • Comprehensive enzymatic activity testing.

Main Results:

  • MoS2/PB nanocomposites exhibit enhanced inter-nanozyme electron transfer from MoS2 to PB.
  • Band modulation effects significantly boost reductase-like catalytic activity.
  • MoS2/PB demonstrates superior catalase, peroxidase, superoxide dismutase, glutathione peroxidase, S-nitrosoglutathione reductase, and nitrite reductase activities.

Conclusions:

  • The proposed interfacial assembly strategy effectively enhances nanozyme activity via electron transfer modulation.
  • Band regulation is a viable method to enrich multiple enzyme activities in composite nanozymes.
  • This work provides a new design paradigm for high-performance nanozymes.